methyl (4'-{[3-(allyloxy)-2-formyl-4-(trifluoromethyl)benzyl]oxy}-1,1'-biphenyl-4-yl)acetate

Base Information

Chemical Name:methyl (4'-{[3-(allyloxy)-2-formyl-4-(trifluoromethyl)benzyl]oxy}-1,1'-biphenyl-4-yl)acetate
CAS No.:873011-30-4
Molecular Formula:C₂₇H₂₃F₃O₅
Molecular Weight:484.472
Hs Code.:

Synonyms:methyl (4'-{[3-(allyloxy)-2-formyl-4-(trifluoromethyl)benzyl]oxy}-1,1'-biphenyl-4-yl)acetate

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Chemical Property of methyl (4'-{[3-(allyloxy)-2-formyl-4-(trifluoromethyl)benzyl]oxy}-1,1'-biphenyl-4-yl)acetate

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Technology Process of methyl (4'-{[3-(allyloxy)-2-formyl-4-(trifluoromethyl)benzyl]oxy}-1,1'-biphenyl-4-yl)acetate

There total 14 articles about methyl (4'-{[3-(allyloxy)-2-formyl-4-(trifluoromethyl)benzyl]oxy}-1,1'-biphenyl-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 873011-29-1
methyl (4'-{[2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzyl]oxy}-1,1'-biphenyl-4-yl)acetate

: 106-95-6
allyl bromide

: 873011-30-4
methyl (4'-{[3-(allyloxy)-2-formyl-4-(trifluoromethyl)benzyl]oxy}-1,1'-biphenyl-4-yl)acetate

Guidance literature:: methyl (4'-{[2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzyl]oxy}-1,1'-biphenyl-4-yl)acetate; With water; toluene-4-sulfonic acid; In acetone; at 20 ℃; for 14h;

allyl bromide; With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 2h;

Reference yield:

: C₂₄H₁₉F₃O₅

: 106-95-6
allyl bromide

: 873011-30-4
methyl (4'-{[3-(allyloxy)-2-formyl-4-(trifluoromethyl)benzyl]oxy}-1,1'-biphenyl-4-yl)acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 2h;

Reference yield:

: 41841-16-1
(4-bromo-phenyl)-acetic acid methyl ester

: 873011-30-4
methyl (4'-{[3-(allyloxy)-2-formyl-4-(trifluoromethyl)benzyl]oxy}-1,1'-biphenyl-4-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; toluene; ethyl acetate / Reflux

2: boron trichloride; tetra-(n-butyl)ammonium iodide / dichloromethane / -78 - 20 °C

3: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 20 °C

4: toluene-4-sulfonic acid / acetone / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 50 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tributylphosphine; boron trichloride; tetra-(n-butyl)ammonium iodide; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; 1: |Suzuki Coupling / 3: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2015.07.047