[(3aR,4E,5R,6aS)-4-ethylidene-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-5-yl]acetic acid 4-hydroxyphenethyl ester

Base Information

Chemical Name:[(3aR,4E,5R,6aS)-4-ethylidene-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-5-yl]acetic acid 4-hydroxyphenethyl ester
CAS No.:869477-01-0
Molecular Formula:C₂₀H₂₆O₅
Molecular Weight:346.423
Hs Code.:

Synonyms:[(3aR,4E,5R,6aS)-4-ethylidene-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-5-yl]acetic acid 4-hydroxyphenethyl ester

Suppliers and Price of [(3aR,4E,5R,6aS)-4-ethylidene-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-5-yl]acetic acid 4-hydroxyphenethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [(3aR,4E,5R,6aS)-4-ethylidene-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-5-yl]acetic acid 4-hydroxyphenethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(3aR,4E,5R,6aS)-4-ethylidene-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-5-yl]acetic acid 4-hydroxyphenethyl ester

There total 6 articles about [(3aR,4E,5R,6aS)-4-ethylidene-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-5-yl]acetic acid 4-hydroxyphenethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104010-72-2
(3aS,6aS)-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-one

: 869477-01-0
[(3aR,4E,5R,6aS)-4-ethylidene-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-5-yl]acetic acid 4-hydroxyphenethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / hydrogen / Pd/C / ethyl acetate / 20 °C

2: 57 percent / LHMDS; HMPA; Me₂Zn / tetrahydrofuran; toluene / -78 - -45 °C

3: LHMDS; CeCl₃ / tetrahydrofuran / -78 - 20 °C

4: LiOH / tetrahydrofuran; methanol; H₂O / 1 h / 20 °C

5: triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hydroxide; cerium(III) chloride; hydrogen; dimethyl zinc(II); triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; water; ethyl acetate; toluene; 3: Wittig reaction / 5: Mitsunobu reaction;
DOI:10.1021/jo071146k

Reference yield:

: 369647-26-7
(4R,5S)-1-(2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl)-2-propen-1-ol

: 869477-01-0
[(3aR,4E,5R,6aS)-4-ethylidene-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-5-yl]acetic acid 4-hydroxyphenethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: Grubbs catalyst / CH₂Cl₂ / 4 h / 23 °C

1.2: 87 percent / pyridinium chlorochromate / CH₂Cl₂ / 12 h / 23 °C

2.1: 95 percent / hydrogen / Pd/C / ethyl acetate / 20 °C

3.1: 57 percent / LHMDS; HMPA; Me₂Zn / tetrahydrofuran; toluene / -78 - -45 °C

4.1: LHMDS; CeCl₃ / tetrahydrofuran / -78 - 20 °C

5.1: LiOH / tetrahydrofuran; methanol; H₂O / 1 h / 20 °C

6.1: triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hydroxide; cerium(III) chloride; hydrogen; dimethyl zinc(II); triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate; palladium on activated charcoal; Grubbs catalyst first generation; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; toluene; 4.1: Wittig reaction / 6.1: Mitsunobu reaction;
DOI:10.1021/jo071146k