Ethyl 6-(chloromethyl)pyridine-2-carboxylate

Base Information

Chemical Name:Ethyl 6-(chloromethyl)pyridine-2-carboxylate
CAS No.:49668-99-7
Molecular Formula:C9H10ClNO2
Molecular Weight:199.637
Hs Code.:29333990
DSSTox Substance ID:DTXSID00575748
Wikidata:Q72473692
Mol file:49668-99-7.mol

Synonyms:49668-99-7;ethyl 6-(chloromethyl)pyridine-2-carboxylate;Ethyl 6-(chloromethyl)picolinate;2-PYRIDINECARBOXYLIC ACID, 6-(CHLOROMETHYL)-, ETHYL ESTER;Ethyl6-(chloromethyl)picolinate;SCHEMBL1698714;2-Pyridinecarboxylicacid, 6-(chloromethyl)-, ethyl ester;DTXSID00575748;UBRNJYSCVHFYDB-UHFFFAOYSA-N;MFCD09878512;AKOS006311099;AB53929;GS-5452;ethyl 6-chloromethylpyridine-2-carboxylate;Ethyl 6-(chloromethyl)-2-pyridinecarboxylate;EN300-342625;A827785;J-521160;2-(chloromethyl)pyridine-6-carboxylic acid ethyl ester;6-(chloromethyl)-2-pyridinecarboxylic acid ethyl ester

Suppliers and Price of Ethyl 6-(chloromethyl)pyridine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl6-(chloromethyl)pyridine-2-carboxylate
100mg
$ 130.00

TRC
Ethyl6-(chloromethyl)pyridine-2-carboxylate
50mg
$ 90.00

TRC
Ethyl6-(chloromethyl)pyridine-2-carboxylate
500mg
$ 475.00

Matrix Scientific
6-Chloromethylpyridine-2-carboxylic acid ethyl ester hydrochloride 95%
10g
$ 1100.00

Matrix Scientific
6-Chloromethylpyridine-2-carboxylic acid ethyl ester hydrochloride 95%
1g
$ 350.00

Matrix Scientific
6-Chloromethylpyridine-2-carboxylic acid ethyl ester hydrochloride 95%
5g
$ 750.00

Labseeker
ETHYL6-(CHLOROMETHYL)PYRIDINE-2-CARBOXYLATE 95
10g
$ 708.00

Frontier Specialty Chemicals
Ethyl6-(chloromethyl)pyridine-2-carboxylate 97%
1g
$ 440.00

Crysdot
Ethyl6-(chloromethyl)picolinate 95+%
1g
$ 342.00

Chemenu
ethyl6-(chloromethyl)picolinate 95%
1g
$ 320.00

Total 30 raw suppliers

Chemical Property of Ethyl 6-(chloromethyl)pyridine-2-carboxylate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.525
Boiling Point:316.327 °C at 760 mmHg
Flash Point:145.11 °C
PSA：39.19000
Density:1.212 g/cm³
LogP:1.99710
Storage Temp.:2-8°C
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:199.0400063
Heavy Atom Count:13
Complexity:175

Purity/Quality:

97% ^*data from raw suppliers

Ethyl6-(chloromethyl)pyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CC=CC(=N1)CCl

Technology Process of Ethyl 6-(chloromethyl)pyridine-2-carboxylate

There total 3 articles about Ethyl 6-(chloromethyl)pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 41337-81-9
ethyl 6-(hydroxymethyl)pyridine-2-carboxylate

: 49668-99-7
ethyl 6-chloromethylpyridine-2-carboxylate

Guidance literature:: With thionyl chloride;
DOI:10.1039/b416150e

Reference yield:

: 15658-60-3
diethyl-2,6-pyridinedicarbonyl ester

: 49668-99-7
ethyl 6-chloromethylpyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 49 percent / NaBH₄ / ethanol / Heating

2: 96 percent / SOCl₂ / 0 °C

With sodium tetrahydroborate; thionyl chloride; In ethanol;
DOI:10.1002/chem.200600915

Reference yield:

: 3739-94-4
2,6-Pyridinedicarbonyl dichloride

: 49668-99-7
ethyl 6-chloromethylpyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 16 h / Reflux

2: sodium tetrahydroborate / ethanol / 16 h / 80 °C

3: thionyl chloride / 18 h / 0 - 20 °C

With sodium tetrahydroborate; thionyl chloride; In ethanol;
DOI:10.1039/c4ra13690j