N-[2-Amino-5-methoxy-4-(5-methyl-4-pyridin-3-yl-1H-imidazol-2-yl)-phenyl]-acetamide

Base Information

• Chemical Name: N-[2-Amino-5-methoxy-4-(5-methyl-4-pyridin-3-yl-1H-imidazol-2-yl)-phenyl]-acetamide
• CAS No.: 1025879-92-8
• Molecular Formula: C₁₈H₁₉N₅O₂
• Molecular Weight: 337.381
• Mol file: 1025879-92-8.mol

Synonyms:N-[2-Amino-5-methoxy-4-(5-methyl-4-pyridin-3-yl-1H-imidazol-2-yl)-phenyl]-acetamide

Chemical Property of N-[2-Amino-5-methoxy-4-(5-methyl-4-pyridin-3-yl-1H-imidazol-2-yl)-phenyl]-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-Amino-5-methoxy-4-(5-methyl-4-pyridin-3-yl-1H-imidazol-2-yl)-phenyl]-acetamide

There total 6 articles about N-[2-Amino-5-methoxy-4-(5-methyl-4-pyridin-3-yl-1H-imidazol-2-yl)-phenyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-acetylamino-2-methoxy-5-nitrophenyl)-5-methyl-4-(3-pyridyl)imidazole (114989-71-8) → N-[2-Amino-5-methoxy-4-(5-methyl-4-pyridin-3-yl-1H-imidazol-2-yl)-phenyl]-acetamide (1025879-92-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; for 4h; under 760 Torr; Ambient temperature;

DOI:10.1248/cpb.42.560

Reference yield:

1-hydroxyimino-1-(3-pyridyl)-2-propanone (65882-96-4) → N-[2-Amino-5-methoxy-4-(5-methyl-4-pyridin-3-yl-1H-imidazol-2-yl)-phenyl]-acetamide (1025879-92-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 79.8 percent / ammonium acetate / acetic acid / 0.25 h / 100 °C

2: 75.8 percent / P(OEt)3 / dimethylformamide / 80 °C

3: H₂ / 10percent Pd/C / methanol; tetrahydrofuran / 4 h / 760 Torr / Ambient temperature

With ammonium acetate; hydrogen; triethyl phosphite; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide;

DOI:10.1248/cpb.42.560

Reference yield:

methyl 4-acetamido-2-methoxy-5-nitrobenzoate (4093-41-8) → N-[2-Amino-5-methoxy-4-(5-methyl-4-pyridin-3-yl-1H-imidazol-2-yl)-phenyl]-acetamide (1025879-92-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 43.8 percent / LiAlH₄ / tetrahydrofuran / 2 h / -30 °C

2: 32.9 percent / MnO₂ / ethyl acetate / 6 h / Heating

3: 79.8 percent / ammonium acetate / acetic acid / 0.25 h / 100 °C

4: 75.8 percent / P(OEt)3 / dimethylformamide / 80 °C

5: H₂ / 10percent Pd/C / methanol; tetrahydrofuran / 4 h / 760 Torr / Ambient temperature

With ammonium acetate; manganese(IV) oxide; lithium aluminium tetrahydride; hydrogen; triethyl phosphite; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1248/cpb.42.560

upstream raw materials:

2-(4-acetylamino-2-methoxy-5-nitrophenyl)-5-methyl-4-(3-pyridyl)imidazole

1-hydroxyimino-1-(3-pyridyl)-2-propanone

methyl 4-acetamido-2-methoxy-5-nitrobenzoate

4-acetylamino-2-methoxy-5-nitrobenzaldehyde