methyl (1R,12E,22S,25S)-22-cyclohexyl-3,23-dioxo-2-oxa-19-thia-4,21,24,28-tetraazapentacyclo[22.2.1.1(4,7).1(17,20).0(6,11)]nonacosa-6,8,10,12,17,20⁽²⁸⁾-hexaene-25-carboxylate

Base Information

• Chemical Name: methyl (1R,12E,22S,25S)-22-cyclohexyl-3,23-dioxo-2-oxa-19-thia-4,21,24,28-tetraazapentacyclo[22.2.1.1(4,7).1(17,20).0(6,11)]nonacosa-6,8,10,12,17,20⁽²⁸⁾-hexaene-25-carboxylate
• CAS No.: 957475-40-0
• Molecular Formula: C₃₁H₃₈N₄O₅S
• Molecular Weight: 578.733

Synonyms:methyl (1R,12E,22S,25S)-22-cyclohexyl-3,23-dioxo-2-oxa-19-thia-4,21,24,28-tetraazapentacyclo[22.2.1.1(4,7).1(17,20).0(6,11)]nonacosa-6,8,10,12,17,20⁽²⁸⁾-hexaene-25-carboxylate

Chemical Property of methyl (1R,12E,22S,25S)-22-cyclohexyl-3,23-dioxo-2-oxa-19-thia-4,21,24,28-tetraazapentacyclo[22.2.1.1(4,7).1(17,20).0(6,11)]nonacosa-6,8,10,12,17,20⁽²⁸⁾-hexaene-25-carboxylate

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Technology Process of methyl (1R,12E,22S,25S)-22-cyclohexyl-3,23-dioxo-2-oxa-19-thia-4,21,24,28-tetraazapentacyclo[22.2.1.1(4,7).1(17,20).0(6,11)]nonacosa-6,8,10,12,17,20⁽²⁸⁾-hexaene-25-carboxylate

There total 1 articles about methyl (1R,12E,22S,25S)-22-cyclohexyl-3,23-dioxo-2-oxa-19-thia-4,21,24,28-tetraazapentacyclo[22.2.1.1(4,7).1(17,20).0(6,11)]nonacosa-6,8,10,12,17,20⁽²⁸⁾-hexaene-25-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R,5S)-1-[(2S)-2-cyclohexyl-2-[(4-pent-4-en-1-yl-1,3-thiazol-2-yl)amino]acetyl]-5-(methoxycarbonyl)pyrrolidin-3-yl-4-vinyl-1,3-dihydro-2H-isoindole-2-carboxylate (957475-39-7) → methyl (1R,12E,22S,25S)-22-cyclohexyl-3,23-dioxo-2-oxa-19-thia-4,21,24,28-tetraazapentacyclo[22.2.1.1(4,7).1(17,20).0(6,11)]nonacosa-6,8,10,12,17,20(28)-hexaene-25-carboxylate (957475-40-0)

Guidance literature:

With 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(i-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methyleneruthenium(II) dichloride; In 1,2-dichloro-ethane; at 85 ℃; for 2h;

DOI:10.1021/jm900524b

Reference yield:

methyl (1R,12E,22S,25S)-22-cyclohexyl-3,23-dioxo-2-oxa-19-thia-4,21,24,28-tetraazapentacyclo[22.2.1.1(4,7).1(17,20).0(6,11)]nonacosa-6,8,10,12,17,20(28)-hexaene-25-carboxylate (957475-40-0) → C30H36N4O5S

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 2h;

DOI:10.1021/jm900524b

upstream raw materials:

(3R,5S)-1-[(2S)-2-cyclohexyl-2-[(4-pent-4-en-1-yl-1,3-thiazol-2-yl)amino]acetyl]-5-(methoxycarbonyl)pyrrolidin-3-yl-4-vinyl-1,3-dihydro-2H-isoindole-2-carboxylate

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