N⁽⁶⁾-benzoyl-8-(prop-1-ynyl)-5'-O-(4,4-dimethoxytrityl)-2'-deoxyadenosine

Base Information

Chemical Name:N⁽⁶⁾-benzoyl-8-(prop-1-ynyl)-5'-O-(4,4-dimethoxytrityl)-2'-deoxyadenosine
CAS No.:204582-49-0
Molecular Formula:C₄₁H₃₇N₅O₆
Molecular Weight:695.775
Hs Code.:

N<sup>(6)</sup>-benzoyl-8-(prop-1-ynyl)-5'-O-(4,4-dimethoxytrityl)-2'-deoxyadenosine

Synonyms:N⁽⁶⁾-benzoyl-8-(prop-1-ynyl)-5'-O-(4,4-dimethoxytrityl)-2'-deoxyadenosine

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Chemical Property of N⁽⁶⁾-benzoyl-8-(prop-1-ynyl)-5'-O-(4,4-dimethoxytrityl)-2'-deoxyadenosine

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Technology Process of N⁽⁶⁾-benzoyl-8-(prop-1-ynyl)-5'-O-(4,4-dimethoxytrityl)-2'-deoxyadenosine

There total 10 articles about N⁽⁶⁾-benzoyl-8-(prop-1-ynyl)-5'-O-(4,4-dimethoxytrityl)-2'-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14985-44-5,90968-89-1
8-bromo-2'-deoxyadenosine

: 204582-49-0
N⁽⁶⁾-benzoyl-8-(prop-1-ynyl)-5'-O-(4,4-dimethoxytrityl)-2'-deoxyadenosine

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N; CuI; Pd(PPh₃)4 / dimethylformamide / 6 h / 50 °C

2: pyridine / 0.5 h / 0 °C

3: pyridine / 2 h / 30 °C

4: aq. NH₃ / 0.5 h

5: Et₃N; 4-(dimethylaminoOpyridine; pyridine / 0.5 h / 0 °C

With pyridine; dmap; ammonium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; 1: Substitution / 2: Silylation / 3: Acylation / 4: Desilylation / 5: Tritylation;
DOI:10.1016/S0960-894X(00)00381-4

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 204582-49-0
N⁽⁶⁾-benzoyl-8-(prop-1-ynyl)-5'-O-(4,4-dimethoxytrityl)-2'-deoxyadenosine

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / pyridine, DMAP / 1 h

2: 98 percent / CuI, NEt₃ / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / dimethylformamide / 4 h

3: pyridine / 0.25 h

4: pyridine / 2 h / Ambient temperature

5: NH₃ / methanol / 1 h

With pyridine; dmap; copper(l) iodide; ammonia; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; N,N-dimethyl-formamide;
DOI:10.1039/a707031d

Reference yield:

: 149540-21-6
5-(6-amino-8-bromo-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol

: 204582-49-0
N⁽⁶⁾-benzoyl-8-(prop-1-ynyl)-5'-O-(4,4-dimethoxytrityl)-2'-deoxyadenosine

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / CuI, NEt₃ / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / dimethylformamide / 4 h

2: pyridine / 0.25 h

3: pyridine / 2 h / Ambient temperature

4: NH₃ / methanol / 1 h

With pyridine; copper(l) iodide; ammonia; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; N,N-dimethyl-formamide;
DOI:10.1039/a707031d