5-(ethylsulfonyl)-2-methyl-3-piperazin-1-yl-N-(2-pyrrolidin-1-ylethyl)-aniline

Base Information

Chemical Name:5-(ethylsulfonyl)-2-methyl-3-piperazin-1-yl-N-(2-pyrrolidin-1-ylethyl)-aniline
CAS No.:871464-79-8
Molecular Formula:C₁₉H₃₂N₄O₂S
Molecular Weight:380.555
Hs Code.:

Synonyms:5-(ethylsulfonyl)-2-methyl-3-piperazin-1-yl-N-(2-pyrrolidin-1-ylethyl)-aniline

Suppliers and Price of 5-(ethylsulfonyl)-2-methyl-3-piperazin-1-yl-N-(2-pyrrolidin-1-ylethyl)-aniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 5-(ethylsulfonyl)-2-methyl-3-piperazin-1-yl-N-(2-pyrrolidin-1-ylethyl)-aniline

Chemical Property:

Boiling Point:618.0±55.0 °C(Predicted)
Density:1.174±0.06 g/cm3(Predicted)

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-(ethylsulfonyl)-2-methyl-3-piperazin-1-yl-N-(2-pyrrolidin-1-ylethyl)-aniline

There total 8 articles about 5-(ethylsulfonyl)-2-methyl-3-piperazin-1-yl-N-(2-pyrrolidin-1-ylethyl)-aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 871339-69-4
1,1-dimethylethyl 4-{5-(ethylsulfonyl)-2-methyl-3-[(2-pyrrolidin-1-ylethyl)amino]phenyl}piperazine-1-carboxylate

: 871464-79-8
5-(ethylsulfonyl)-2-methyl-3-piperazin-1-yl-N-(2-pyrrolidin-1-ylethyl)-aniline

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; for 0.0166667h; Heating / reflux;

Reference yield:

: 871339-65-0
3,5-dibromo-4-methylbenzenethiol

: 871464-79-8
5-(ethylsulfonyl)-2-methyl-3-piperazin-1-yl-N-(2-pyrrolidin-1-ylethyl)-aniline

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 0 - 20 °C

3: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 17 h / 100 °C

4: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 2 h / 100 °C

5: hydrogenchloride / 1,4-dioxane; methanol / 0.02 h / Heating / reflux

With hydrogenchloride; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 871339-63-8
O-(3,5-dibromo-4-methylphenyl)dimethylthiocarbamate

: 871464-79-8
5-(ethylsulfonyl)-2-methyl-3-piperazin-1-yl-N-(2-pyrrolidin-1-ylethyl)-aniline

Guidance literature:: Multi-step reaction with 7 steps

1.1: 23 h / 200 °C / Neat (no solvent)

2.1: sodium hydroxide; water / methanol / 1.5 h / Heating / reflux

2.2: pH 3

3.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 0 - 20 °C

5.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 17 h / 100 °C

6.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 2 h / 100 °C

7.1: hydrogenchloride / 1,4-dioxane; methanol / 0.02 h / Heating / reflux

With hydrogenchloride; sodium hydroxide; water; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;