2-(4-azido-3-methylphenyl)-4-acetyl-5-(3,4,5-trimethoxyphenyl)-Δ2,3-oxadiazoline

Base Information

Chemical Name:2-(4-azido-3-methylphenyl)-4-acetyl-5-(3,4,5-trimethoxyphenyl)-Δ2,3-oxadiazoline
CAS No.:380922-30-5
Molecular Formula:C₂₀H₂₁N₅O₅
Molecular Weight:411.417
Hs Code.:

Synonyms:2-(4-azido-3-methylphenyl)-4-acetyl-5-(3,4,5-trimethoxyphenyl)-Δ2,3-oxadiazoline

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Chemical Property of 2-(4-azido-3-methylphenyl)-4-acetyl-5-(3,4,5-trimethoxyphenyl)-Δ2,3-oxadiazoline

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Technology Process of 2-(4-azido-3-methylphenyl)-4-acetyl-5-(3,4,5-trimethoxyphenyl)-Δ2,3-oxadiazoline

There total 6 articles about 2-(4-azido-3-methylphenyl)-4-acetyl-5-(3,4,5-trimethoxyphenyl)-Δ2,3-oxadiazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 108-24-7
acetic anhydride

: 4-azido-3-methylbenzoic acid (3,4,5-trimethoxybenzylidene)hydrazone

: 380922-30-5
2-(4-azido-3-methylphenyl)-4-acetyl-5-(3,4,5-trimethoxyphenyl)-Δ2,3-oxadiazoline

Guidance literature:: at 125 ℃; for 2h;
DOI:10.1021/jm010231w

Reference yield:

: 2486-70-6
4-amino 3-methylbenzoic acid

: 380922-30-5
2-(4-azido-3-methylphenyl)-4-acetyl-5-(3,4,5-trimethoxyphenyl)-Δ2,3-oxadiazoline

Guidance literature:: Multi-step reaction with 7 steps

1.1: 96 percent / diethyl ether

2.1: H₂SO₄; NaNO₂ / H₂O / 0.75 h

2.2: 90 percent / NaN₃ / H₂O / 0.17 h

3.1: 95 percent / 25percent aq. NaOH / ethanol / 1 h / 20 °C

4.1: EDCI; 4-(N,N-dimethylamino)pyridine / tetrahydrofuran; dimethylformamide / 17 h / 20 °C

5.1: 1.02 g / trifluoroacetic acid / CH₂Cl₂ / 2 h / 0 °C

6.1: 67 percent / AcOH / ethanol / 0.33 h

7.1: 64 percent / 2 h / 125 °C

With dmap; sulfuric acid; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium nitrite; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm010231w

Reference yield:

: 380922-31-6
4-azido-3-methylbenzoic acid

: 380922-30-5
2-(4-azido-3-methylphenyl)-4-acetyl-5-(3,4,5-trimethoxyphenyl)-Δ2,3-oxadiazoline

Guidance literature:: Multi-step reaction with 4 steps

1: EDCI; 4-(N,N-dimethylamino)pyridine / tetrahydrofuran; dimethylformamide / 17 h / 20 °C

2: 1.02 g / trifluoroacetic acid / CH₂Cl₂ / 2 h / 0 °C

3: 67 percent / AcOH / ethanol / 0.33 h

4: 64 percent / 2 h / 125 °C

With dmap; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010231w