14-epi-2α-methyl-1α,25(OH)2-6,7-dehydro-19-norvitamin D3

Base Information

Chemical Name:14-epi-2α-methyl-1α,25(OH)2-6,7-dehydro-19-norvitamin D3
CAS No.:1227058-10-7
Molecular Formula:C₂₇H₄₂O₃
Molecular Weight:414.629
Hs Code.:

Synonyms:14-epi-2α-methyl-1α,25(OH)2-6,7-dehydro-19-norvitamin D3

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Chemical Property of 14-epi-2α-methyl-1α,25(OH)2-6,7-dehydro-19-norvitamin D3

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Technology Process of 14-epi-2α-methyl-1α,25(OH)2-6,7-dehydro-19-norvitamin D3

There total 9 articles about 14-epi-2α-methyl-1α,25(OH)2-6,7-dehydro-19-norvitamin D3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1227058-16-3
14-epi-2-methylene-1α,25(OH)2-6,7-dehydro-19-norvitamin D3

: 1227058-10-7
14-epi-2α-methyl-1α,25(OH)2-6,7-dehydro-19-norvitamin D3

: 1227058-09-4
14-epi-2β-methyl-1α,25(OH)2-6,7-dehydro-19-norvitamin D3

Guidance literature:: With Wilkinson's catalyst; hydrogen; In dichloromethane; benzene; at 20 ℃; for 1h;
DOI:10.1021/ja201481j

Reference yield:

: 1227058-15-2
C₂₀H₄₀O₃Si₂

: 1227058-10-7
14-epi-2α-methyl-1α,25(OH)2-6,7-dehydro-19-norvitamin D3

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetra-n-propylammonium perruthenate.; 4-methylmorpholine N-oxide / dichloromethane / 0 - 20 °C / Molecular sieve; Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; diethyl ether; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 2.25 h / -78 - 0 °C / Inert atmosphere

3.1: copper(l) iodide; bis(acetato)bis(triphenylphosphine)palladium⁽⁰⁾; diethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

5.1: Wilkinson's catalyst; hydrogen / dichloromethane; benzene / 1 h / 20 °C

With copper(l) iodide; Wilkinson's catalyst; n-butyllithium; bis(acetato)bis(triphenylphosphine)palladium⁽⁰⁾; tetra-n-propylammonium perruthenate.; tetrabutyl ammonium fluoride; hydrogen; 4-methylmorpholine N-oxide; diethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; benzene; 3.1: Sonogashira coupling reaction;
DOI:10.1021/ja201481j

Reference yield:

: 1227058-13-0
(3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-1-ethynyl-4-methylenecyclohex-1-ene

: 1227058-10-7
14-epi-2α-methyl-1α,25(OH)2-6,7-dehydro-19-norvitamin D3

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; bis(acetato)bis(triphenylphosphine)palladium⁽⁰⁾; diethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: Wilkinson's catalyst; hydrogen / dichloromethane; benzene / 1 h / 20 °C

With copper(l) iodide; Wilkinson's catalyst; bis(acetato)bis(triphenylphosphine)palladium⁽⁰⁾; tetrabutyl ammonium fluoride; hydrogen; diethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene; 1: Sonogashira coupling reaction;
DOI:10.1021/ja201481j