6‘-bromo-2,3,5,6-tetrahydrospiro[pyran-4,3‘-pyrrolo[3 ,2-b]pyridin]-2‘(1‘H)-one

Base Information

Chemical Name:6‘-bromo-2,3,5,6-tetrahydrospiro[pyran-4,3‘-pyrrolo[3 ,2-b]pyridin]-2‘(1‘H)-one
CAS No.:1190862-19-1
Molecular Formula:C₁₁H₁₁BrN₂O₂
Molecular Weight:283.125
Hs Code.:

Synonyms:6‘-bromo-2,3,5,6-tetrahydrospiro[pyran-4,3‘-pyrrolo[3 ,2-b]pyridin]-2‘(1‘H)-one

Suppliers and Price of 6‘-bromo-2,3,5,6-tetrahydrospiro[pyran-4,3‘-pyrrolo[3 ,2-b]pyridin]-2‘(1‘H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6‘-bromo-2,3,5,6-tetrahydrospiro[pyran-4,3‘-pyrrolo[3 ,2-b]pyridin]-2‘(1‘H)-one

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of 6‘-bromo-2,3,5,6-tetrahydrospiro[pyran-4,3‘-pyrrolo[3 ,2-b]pyridin]-2‘(1‘H)-one

There total 1 articles about 6‘-bromo-2,3,5,6-tetrahydrospiro[pyran-4,3‘-pyrrolo[3 ,2-b]pyridin]-2‘(1‘H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1190862-19-1
6‘-bromo-2,3,5,6-tetrahydrospiro[pyran-4,3‘-pyrrolo[3 ,2-b]pyridin]-2‘(1‘H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / Inert atmosphere; Cooling with ice

1.2: 0.25 h / 20 °C / Inert atmosphere

2.1: lithium chloride / water; dimethyl sulfoxide / 150 °C / Inert atmosphere

3.1: hydrogen / tetrahydrofuran / 1551.49 Torr / Inert atmosphere

4.1: acetic acid / toluene / 4 h / Inert atmosphere; Reflux

5.1: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

5.2: 60 °C / Inert atmosphere

With hydrogen; sodium hydride; potassium carbonate; acetic acid; lithium chloride; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm300679u

Reference yield:

: 515135-67-8
N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)benzamide

: 1190862-19-1
6‘-bromo-2,3,5,6-tetrahydrospiro[pyran-4,3‘-pyrrolo[3 ,2-b]pyridin]-2‘(1‘H)-one

: 1190860-44-6
N-cyclopropyl-4-methyl-3-(2'-oxo-1',2,2',3,5,6-hexahydrospiro[pyran-4,3'-pyrrolo-[3,2-b]pyridin]-6'-yl)benzamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; water; at 90 - 100 ℃;
DOI:10.1016/j.bmcl.2011.07.033