(1R,2R,3R)-2-Benzoyl-3-((R)-1,2-dihydroxy-ethyl)-cyclopropanecarboxylic acid diethylamide

Base Information

Chemical Name:(1R,2R,3R)-2-Benzoyl-3-((R)-1,2-dihydroxy-ethyl)-cyclopropanecarboxylic acid diethylamide
CAS No.:233758-90-2
Molecular Formula:C₁₇H₂₃NO₄
Molecular Weight:305.374
Hs Code.:

Synonyms:(1R,2R,3R)-2-Benzoyl-3-((R)-1,2-dihydroxy-ethyl)-cyclopropanecarboxylic acid diethylamide

Suppliers and Price of (1R,2R,3R)-2-Benzoyl-3-((R)-1,2-dihydroxy-ethyl)-cyclopropanecarboxylic acid diethylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (1R,2R,3R)-2-Benzoyl-3-((R)-1,2-dihydroxy-ethyl)-cyclopropanecarboxylic acid diethylamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (1R,2R,3R)-2-Benzoyl-3-((R)-1,2-dihydroxy-ethyl)-cyclopropanecarboxylic acid diethylamide

There total 7 articles about (1R,2R,3R)-2-Benzoyl-3-((R)-1,2-dihydroxy-ethyl)-cyclopropanecarboxylic acid diethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20913-05-7,859-65-4
(Benzoylmethylene)triphenylphosphorane

: 233758-90-2
(1R,2R,3R)-2-Benzoyl-3-((R)-1,2-dihydroxy-ethyl)-cyclopropanecarboxylic acid diethylamide

Guidance literature:: Multi-step reaction with 5 steps

1: methanol / 0 °C

2: DBU / toluene / 4 h / -20 °C

3: 2.15 g / NaOH / aq. ethanol / 10 h / 0 °C

4: 1.93 g / HOBt; DCC / CH₂Cl₂ / 20 °C

5: aq. HCl / methanol

With hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; In methanol; ethanol; dichloromethane; toluene; 1: Wittig reaction;
DOI:10.1021/ol990598j

Reference yield:

: 233758-84-4
(R)-3-(2,2-dimethyl-[1,3]dioxolan-4-yl)-1-phenyl-prop-2E-en-1-one

: 233758-90-2
(1R,2R,3R)-2-Benzoyl-3-((R)-1,2-dihydroxy-ethyl)-cyclopropanecarboxylic acid diethylamide

Guidance literature:: Multi-step reaction with 4 steps

1: DBU / toluene / 4 h / -20 °C

2: 2.15 g / NaOH / aq. ethanol / 10 h / 0 °C

3: 1.93 g / HOBt; DCC / CH₂Cl₂ / 20 °C

4: aq. HCl / methanol

With hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; In methanol; ethanol; dichloromethane; toluene;
DOI:10.1021/ol990598j