1-bromo-4-[(1α,5α,6β)-3-tert-butoxycarbonyl-6-cyano-3-azabicyclo[3.1.0]hexan-6-yl]benzene

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Chemical Name:1-bromo-4-[(1α,5α,6β)-3-tert-butoxycarbonyl-6-cyano-3-azabicyclo[3.1.0]hexan-6-yl]benzene
CAS No.:831202-95-0
Molecular Formula:C₁₇H₁₉BrN₂O₂
Molecular Weight:363.254
Hs Code.:

Synonyms:1-bromo-4-[(1α,5α,6β)-3-tert-butoxycarbonyl-6-cyano-3-azabicyclo[3.1.0]hexan-6-yl]benzene

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Chemical Property of 1-bromo-4-[(1α,5α,6β)-3-tert-butoxycarbonyl-6-cyano-3-azabicyclo[3.1.0]hexan-6-yl]benzene

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Technology Process of 1-bromo-4-[(1α,5α,6β)-3-tert-butoxycarbonyl-6-cyano-3-azabicyclo[3.1.0]hexan-6-yl]benzene

There total 1 articles about 1-bromo-4-[(1α,5α,6β)-3-tert-butoxycarbonyl-6-cyano-3-azabicyclo[3.1.0]hexan-6-yl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 16532-79-9
4-Bromophenylacetonitrile

: 831203-12-4
cis-N-tert-butoxycarbonylpyrrolidine-3,4-cyclic sulfate

: 831202-95-0
1-bromo-4-[(1α,5α,6β)-3-tert-butoxycarbonyl-6-cyano-3-azabicyclo[3.1.0]hexan-6-yl]benzene

Guidance literature:: With sodium hydride; In 1,2-dimethoxyethane; mineral oil; at 0 - 20 ℃; stereoselective reaction;
DOI:10.1021/jm800800c

Reference yield: 72.0%

: 700370-33-8
(5R)-3-[3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one

: 831202-95-0
1-bromo-4-[(1α,5α,6β)-3-tert-butoxycarbonyl-6-cyano-3-azabicyclo[3.1.0]hexan-6-yl]benzene

: 1-[5(R)-3-[4-[4-[(1α,5α,6β)-3-tert-butoxycarbonyl-6-cyano-3-azabicyclo[3.1.0]hexan-6-yl]phenyl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 80 ℃; for 3h;
DOI:10.1021/jm800800c