1,1-dimethylethyl (2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1,1-dimethyl-2-oxoethyl)carbamate

Base Information

Chemical Name:1,1-dimethylethyl (2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1,1-dimethyl-2-oxoethyl)carbamate
CAS No.:953391-64-5
Molecular Formula:C₂₇H₃₂FN₃O₇S
Molecular Weight:561.631
Hs Code.:

Synonyms:1,1-dimethylethyl (2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1,1-dimethyl-2-oxoethyl)carbamate

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Chemical Property of 1,1-dimethylethyl (2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1,1-dimethyl-2-oxoethyl)carbamate

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Technology Process of 1,1-dimethylethyl (2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1,1-dimethyl-2-oxoethyl)carbamate

There total 4 articles about 1,1-dimethylethyl (2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1,1-dimethyl-2-oxoethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 953391-63-4
N-[5-amino-2-(methyloxy)phenyl]-3-fluoro-4-(5-methyl-2-furanyl)benzenesulfonamide

: 30992-29-1
Boc-Aib-OH

: 953391-64-5
1,1-dimethylethyl (2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1,1-dimethyl-2-oxoethyl)carbamate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 22h;

Reference yield:

: 953391-61-2
4-bromo-3-fluoro-N-[2-(methyloxy)-5-nitrophenyl]benzenesulfonamide

: 953391-64-5
1,1-dimethylethyl (2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1,1-dimethyl-2-oxoethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 6 h / Heating / reflux

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 18 - 24 h

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 22 h / 20 °C

With hydrogen; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 351003-51-5
4-bromo-3-fluorobenzene-1-sulfonyl chloride

: 953391-64-5
1,1-dimethylethyl (2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1,1-dimethyl-2-oxoethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 0.5 - 2 h / 0 - 20 °C

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 6 h / Heating / reflux

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 18 - 24 h

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 22 h / 20 °C

With pyridine; hydrogen; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;