methyl (2S)-2-((1S)-5-{2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy}-2,3-dihydro-1H-inden-1-yl)butanoate

Base Information

Chemical Name:methyl (2S)-2-((1S)-5-{2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy}-2,3-dihydro-1H-inden-1-yl)butanoate
CAS No.:496060-66-3
Molecular Formula:C₂₇H₃₁NO₄
Molecular Weight:433.547
Hs Code.:

Synonyms:methyl (2S)-2-((1S)-5-{2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy}-2,3-dihydro-1H-inden-1-yl)butanoate

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Chemical Property of methyl (2S)-2-((1S)-5-{2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy}-2,3-dihydro-1H-inden-1-yl)butanoate

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Technology Process of methyl (2S)-2-((1S)-5-{2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy}-2,3-dihydro-1H-inden-1-yl)butanoate

There total 11 articles about methyl (2S)-2-((1S)-5-{2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy}-2,3-dihydro-1H-inden-1-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 157169-71-6
2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethanol

: methyl (2S)-2-[(1S)-5-hydroxy-2,3-dihydro-1H-inden-1-yl]butanoate

: 496060-66-3
methyl (2S)-2-((1S)-5-{2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy}-2,3-dihydro-1H-inden-1-yl)butanoate

Guidance literature:: With triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

: 496060-61-8
(2S)-2-[(1S)-5-methoxy-2,3-dihydro-1H-inden-1-yl]butanoic acid

: 496060-66-3
methyl (2S)-2-((1S)-5-{2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy}-2,3-dihydro-1H-inden-1-yl)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 42 h / 20 °C / Inert atmosphere

2: aluminum (III) chloride; ethanethiol / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere

With aluminum (III) chloride; sodium hydrogencarbonate; triphenylphosphine; ethanethiol; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3: |Mitsunobu Displacement;

Reference yield:

: 874-60-2
4-methyl-benzoyl chloride

: 496060-66-3
methyl (2S)-2-((1S)-5-{2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy}-2,3-dihydro-1H-inden-1-yl)butanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: chloro-trimethyl-silane; triethylamine / dichloromethane / 1 h / 5 - 25 °C

1.2: 16 h / 10 - 20 °C

2.1: dmap; pyridine / 2 h / 90 °C

3.1: acetic anhydride; sulfuric acid / 80 °C

4.1: lithium borohydride / tetrahydrofuran / 45 °C

5.1: triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere

With pyridine; dmap; lithium borohydride; chloro-trimethyl-silane; sulfuric acid; acetic anhydride; triethylamine; triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; dichloromethane; 5.1: |Mitsunobu Displacement;