N-(2-aminophenyl)-4-{[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)(3-pyridinylmethyl)amino]-methyl}benzamide

Base Information

Chemical Name:N-(2-aminophenyl)-4-{[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)(3-pyridinylmethyl)amino]-methyl}benzamide
CAS No.:905818-84-0
Molecular Formula:C₂₈H₃₈N₄O₂Si
Molecular Weight:490.721
Hs Code.:

Synonyms:N-(2-aminophenyl)-4-{[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)(3-pyridinylmethyl)amino]-methyl}benzamide

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Chemical Property of N-(2-aminophenyl)-4-{[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)(3-pyridinylmethyl)amino]-methyl}benzamide

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Technology Process of N-(2-aminophenyl)-4-{[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)(3-pyridinylmethyl)amino]-methyl}benzamide

There total 6 articles about N-(2-aminophenyl)-4-{[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)(3-pyridinylmethyl)amino]-methyl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 905818-83-9
4-{[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)(3-pyridinylmethyl)amino]methyl}-N-(2-nitrophenyl)benzamide

: 905818-84-0
N-(2-aminophenyl)-4-{[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)(3-pyridinylmethyl)amino]-methyl}benzamide

Guidance literature:: With ammonium acetate; tin(ll) chloride; In methanol; at 60 ℃; for 1h;
DOI:10.1016/j.ejmech.2006.02.002

Reference yield:

: 905818-80-6
tert-butyl 4-[(2-nitroanilino)carbonyl]benzylcarbamate

: 905818-84-0
N-(2-aminophenyl)-4-{[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)(3-pyridinylmethyl)amino]-methyl}benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / aq. HCl / methanol / 13 h / 20 °C

2: 33.5 percent / Et₃N; AcOH; NaBH₃CN / methanol / 6 h / 20 °C

3: 36.6 percent / AcOH; NaBH₃CN / methanol / 6 h / 20 °C

4: 59 percent / SnCl₂*2H₂O; NH₄OAc / methanol / 1 h / 60 °C

With hydrogenchloride; ammonium acetate; sodium cyanoborohydride; acetic acid; triethylamine; tin(ll) chloride; In methanol;
DOI:10.1016/j.ejmech.2006.02.002

Reference yield:

: 905818-82-8
4-{[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]methyl}-N-(2-nitrophenyl)benzamide

: 905818-84-0
N-(2-aminophenyl)-4-{[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)(3-pyridinylmethyl)amino]-methyl}benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 36.6 percent / AcOH; NaBH₃CN / methanol / 6 h / 20 °C

2: 59 percent / SnCl₂*2H₂O; NH₄OAc / methanol / 1 h / 60 °C

With ammonium acetate; sodium cyanoborohydride; acetic acid; tin(ll) chloride; In methanol;
DOI:10.1016/j.ejmech.2006.02.002