tert-butyl 2,3,5,6-tetrafluorobenzoate

Base Information

• Chemical Name: tert-butyl 2,3,5,6-tetrafluorobenzoate
• CAS No.: 1567382-94-8
• Molecular Formula: C₁₁H₁₀F₄O₂
• Molecular Weight: 250.193
• Mol file: 1567382-94-8.mol

Synonyms:tert-butyl 2,3,5,6-tetrafluorobenzoate

Chemical Property of tert-butyl 2,3,5,6-tetrafluorobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2,3,5,6-tetrafluorobenzoate

There total 2 articles about tert-butyl 2,3,5,6-tetrafluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl 2,3,4,5,6-pentafluorobenzoate (98040-93-8) → tert-butyl 2,3,5,6-tetrafluorobenzoate (1567382-94-8)

Guidance literature:

With H₂SiEt₂; tetrabutylammonium triphenyldifluorosilicate; In tetrahydrofuran; benzene-d6; at 40 ℃; for 20h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201708003

Reference yield:

Pentafluorobenzoic acid (602-94-8) → tert-butyl 2,3,5,6-tetrafluorobenzoate (1567382-94-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / tert-butyl alcohol / 18 h / 40 °C

2: tris[2-phenylpyridinato-C₂,N]iridium(III); N-ethyl-N,N-diisopropylamine / acetonitrile; benzene-d6 / 45 h / 0 °C / Inert atmosphere; Irradiation

With dmap; tris[2-phenylpyridinato-C₂,N]iridium(III); N-ethyl-N,N-diisopropylamine; In benzene-d6; acetonitrile; tert-butyl alcohol;

DOI:10.1021/ja500031m

Reference yield: 46.0%

tert-butyl 2,3,5,6-tetrafluorobenzoate (1567382-94-8) + C9H10ClIO2 → tert-butyl 2,3,5,6-tetrafluoro-4-(5-methoxy-2,3-dihydrobenzofuran-4-yl)benzoate

Guidance literature:

With copper(l) iodide; 2-(diphenylphosphino)pyridine; norbornene; palladium diacetate; caesium carbonate; In acetonitrile; at 120 ℃; for 24h; Sealed tube; Inert atmosphere;

DOI:10.1039/c8cc00489g

upstream raw materials:

Pentafluorobenzoic acid

tert-butyl 2,3,4,5,6-pentafluorobenzoate