diethyl 3-(N-(benzyloxy)-4-phenylbutanamido)propylphosphonate

Base Information

• Chemical Name: diethyl 3-(N-(benzyloxy)-4-phenylbutanamido)propylphosphonate
• CAS No.: 1417649-97-8
• Molecular Formula: C₂₄H₃₄NO₅P
• Molecular Weight: 447.511
• Mol file: 1417649-97-8.mol

Synonyms:diethyl 3-(N-(benzyloxy)-4-phenylbutanamido)propylphosphonate

Chemical Property of diethyl 3-(N-(benzyloxy)-4-phenylbutanamido)propylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 3-(N-(benzyloxy)-4-phenylbutanamido)propylphosphonate

There total 3 articles about diethyl 3-(N-(benzyloxy)-4-phenylbutanamido)propylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

phenylbutyric acid chloride (18496-54-3) + O-(benzylhydroxylamino)propylphosphonic acid diethyl ester (557090-55-8) → diethyl 3-(N-(benzyloxy)-4-phenylbutanamido)propylphosphonate (1417649-97-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1039/c3md00085k

Reference yield:

diethyl 3,3-diethoxypropylphosphonate (15110-17-5) → diethyl 3-(N-(benzyloxy)-4-phenylbutanamido)propylphosphonate (1417649-97-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / water

2: methanol / 40 °C

3: triethylamine / dichloromethane / 0 - 20 °C

With hydrogenchloride; triethylamine; In methanol; dichloromethane; water;

DOI:10.1039/c3md00085k

Reference yield:

diethyl (3-oxopropyl)phosphonate (3986-95-6) → diethyl 3-(N-(benzyloxy)-4-phenylbutanamido)propylphosphonate (1417649-97-8)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 40 °C

2: triethylamine / dichloromethane / 0 - 20 °C

With triethylamine; In methanol; dichloromethane;

DOI:10.1039/c3md00085k

upstream raw materials:

diethyl 3,3-diethoxypropylphosphonate

diethyl (3-oxopropyl)phosphonate

phenylbutyric acid chloride

O-(benzylhydroxylamino)propylphosphonic acid diethyl ester

Downstream raw materials:

diethyl 3-(N-hydroxy-4-phenylbutanamido)propylphosphonate

C₁₃H₂₀NO₅P

sodium hydrogen 3-(N-hydroxy-4-phenylbutanamido)propylphosphonate