methyl 4-(1-(2-chloro-6-methyl-4-morpholinobenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Base Information

Chemical Name:methyl 4-(1-(2-chloro-6-methyl-4-morpholinobenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate
CAS No.:1562995-88-3
Molecular Formula:C₂₆H₂₂ClFN₄O₄
Molecular Weight:508.936
Hs Code.:

Synonyms:methyl 4-(1-(2-chloro-6-methyl-4-morpholinobenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

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Chemical Property of methyl 4-(1-(2-chloro-6-methyl-4-morpholinobenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

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Technology Process of methyl 4-(1-(2-chloro-6-methyl-4-morpholinobenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

There total 8 articles about methyl 4-(1-(2-chloro-6-methyl-4-morpholinobenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 110-91-8,99108-56-2
morpholine

: 1562995-86-1
methyl 4-(1-(4-bromo-2-chloro-6-methylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

: 1562995-88-3
methyl 4-(1-(2-chloro-6-methyl-4-morpholinobenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; DavePhos; In toluene; at 100 ℃; for 2h; Inert atmosphere;

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 1562995-88-3
methyl 4-(1-(2-chloro-6-methyl-4-morpholinobenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: N-chloro-succinimide; palladium diacetate / N,N-dimethyl-formamide / 12 h / 100 °C / Inert atmosphere

2: oxalyl dichloride / N,N-dimethyl-formamide / 1 h / 20 °C

3: dmap; triethylamine / dichloromethane / 2 h / 20 °C

4: sodium t-butanolate; DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 2 h / 100 °C / Inert atmosphere

With dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-chloro-succinimide; oxalyl dichloride; palladium diacetate; triethylamine; sodium t-butanolate; DavePhos; In dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 633328-40-2
3-iodo-1H-pyrazolo[4,3-b]pyridine

: 1562995-88-3
methyl 4-(1-(2-chloro-6-methyl-4-morpholinobenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / tetrahydrofuran / 6 h / Reflux

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / toluene; ethanol / 6 h / 120 °C / Inert atmosphere

3: hydrogenchloride / methanol / 14 h / Reflux

4: dmap; triethylamine / dichloromethane / 2 h / 20 °C

5: sodium t-butanolate; DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 2 h / 100 °C / Inert atmosphere

With hydrogenchloride; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; toluene-4-sulfonic acid; triethylamine; sodium t-butanolate; DavePhos; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene; 2: |Suzuki Coupling;