2-(1-benzyloxy-1-methyl-propyl)-11-hydroxy-5-methyl-1-oxa-benzo[a]anthracene-4,7,12-trione

Base Information

Chemical Name:2-(1-benzyloxy-1-methyl-propyl)-11-hydroxy-5-methyl-1-oxa-benzo[a]anthracene-4,7,12-trione
CAS No.:919110-94-4
Molecular Formula:C₂₉H₂₄O₆
Molecular Weight:468.506
Hs Code.:

2-(1-benzyloxy-1-methyl-propyl)-11-hydroxy-5-methyl-1-oxa-benzo[<i>a</i>]anthracene-4,7,12-trione

Synonyms:2-(1-benzyloxy-1-methyl-propyl)-11-hydroxy-5-methyl-1-oxa-benzo[a]anthracene-4,7,12-trione

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Chemical Property of 2-(1-benzyloxy-1-methyl-propyl)-11-hydroxy-5-methyl-1-oxa-benzo[a]anthracene-4,7,12-trione

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Technology Process of 2-(1-benzyloxy-1-methyl-propyl)-11-hydroxy-5-methyl-1-oxa-benzo[a]anthracene-4,7,12-trione

There total 15 articles about 2-(1-benzyloxy-1-methyl-propyl)-11-hydroxy-5-methyl-1-oxa-benzo[a]anthracene-4,7,12-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 919110-81-9
2-((R)-4-Benzyloxy-4-methyl-hex-2-ynoyl)-1,8-dihydroxy-3-methyl-anthraquinone

: 919110-94-4
2-(1-benzyloxy-1-methyl-propyl)-11-hydroxy-5-methyl-1-oxa-benzo[a]anthracene-4,7,12-trione

Guidance literature:: With caesium carbonate; In acetone; at 20 ℃; for 0.5h;
DOI:10.1021/ol062492b

Reference yield:

: 919110-88-6
(R)-2-Benzyloxy-2-methyl-butan-1-ol

: 919110-94-4
2-(1-benzyloxy-1-methyl-propyl)-11-hydroxy-5-methyl-1-oxa-benzo[a]anthracene-4,7,12-trione

Guidance literature:: Multi-step reaction with 8 steps

1.1: 92 percent / IBX / CH₂Cl₂; dimethylsulfoxide / 8 h / 20 °C

2.1: Zn; Ph₃P / CH₂Cl₂ / 0.5 h / 20 °C

2.2: 84 percent / CH₂Cl₂ / 6 h / 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -78 - -20 °C

3.2: 80 percent / tetrahydrofuran; hexane / 3 h / -78 - 20 °C

4.1: 86 percent / n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C

5.1: 90 percent / AgO; HNO₃ / dioxane / 0.5 h / 20 °C

6.1: 93 percent / IBX / dimethylsulfoxide; CH₂Cl₂ / 5 h / 20 °C

7.1: 88 percent / H₂SO₄ / acetic acid / 0.5 h / 55 °C

8.1: 65 percent / Cs₂CO₃ / acetone / 0.5 h / 20 °C

With silver(II) oxide; n-butyllithium; sulfuric acid; nitric acid; caesium carbonate; triphenylphosphine; zinc; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; acetic acid; dimethyl sulfoxide; acetone;
DOI:10.1021/ol062492b

Reference yield:

: 919110-83-1
(R)-4-Benzyloxy-4-methyl-hex-2-ynal

: 919110-94-4
2-(1-benzyloxy-1-methyl-propyl)-11-hydroxy-5-methyl-1-oxa-benzo[a]anthracene-4,7,12-trione

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C

2: 90 percent / AgO; HNO₃ / dioxane / 0.5 h / 20 °C

3: 93 percent / IBX / dimethylsulfoxide; CH₂Cl₂ / 5 h / 20 °C

4: 88 percent / H₂SO₄ / acetic acid / 0.5 h / 55 °C

5: 65 percent / Cs₂CO₃ / acetone / 0.5 h / 20 °C

With silver(II) oxide; n-butyllithium; sulfuric acid; nitric acid; caesium carbonate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; acetic acid; dimethyl sulfoxide; acetone;
DOI:10.1021/ol062492b