5-PHENYL-2-THIOPHENESULFONYL CHLORIDE

Base Information

• Chemical Name: 5-PHENYL-2-THIOPHENESULFONYL CHLORIDE
• CAS No.: 97272-02-1
• Molecular Formula: C10H7ClO2S2
• Molecular Weight: 258.749
• Hs Code.: 2934999090
• Mol file: 97272-02-1.mol

Synonyms:2-Chlorosulfonyl-5-phenylthiophene;5-Phenylthiophene-2-sulfonyl chloride;

Chemical Property of 5-PHENYL-2-THIOPHENESULFONYL CHLORIDE

Chemical Property:

• Vapor Pressure: 3.65E-06mmHg at 25°C
• Melting Point: 85-87 °C
• Refractive Index: 1.616
• Boiling Point: 397.4 °C at 760 mmHg
• Flash Point: 194.1 °C
• PSA: 70.76000
• Density: 1.43 g/cm³
• LogP: 4.42340

Purity/Quality:

98%min ^*data from raw suppliers

5-Phenylthiophene-2-sulfonyl chloride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C,Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-PHENYL-2-THIOPHENESULFONYL CHLORIDE

There total 7 articles about 5-PHENYL-2-THIOPHENESULFONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

C10H7LiO2S2 → 5-phenyl-2-thiophenesulphonyl chloride (97272-02-1)

Guidance literature:

With sulfuryl dichloride; In hexane; at 0 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1021/jm801394m

Reference yield: 77.0%

N-(pyrrole)-5-(phenyl)thiophene-2-sulfonamide (184041-12-1) → 5-phenyl-2-thiophenesulphonyl chloride (97272-02-1)

Guidance literature:

Reference yield: 60.0%

→ 5-phenyl-2-thiophenesulphonyl chloride (97272-02-1)

Guidance literature:

upstream raw materials:

2-phenylthiophene

N,N-dimethyl-formamide

3-phenylthiophene

N-(pyrrole)-5-(phenyl)thiophene-2-sulfonamide

Downstream raw materials:

N,N'-benzene-1,2-diylbis(5-phenylthiophene-2-sulfonamide)

Refernces

• 1、 Monovich, Lauren G.,Tommasi, Ruben A.,Fujimoto, Roger A.,Blancuzzi, Vincent,Clark, Kirk,Cornell, Wendy D.,Doti, Robert,Doughty, John,Fang, James,Farley, David,Fitt, John,Ganu, Vishwas,Goldberg, Ronald,Goldstein, Robert,Lavoie, Stacey,Kulathila, Raviraj,Macchia, William,Parker, David T.,Melton, Richard,O'Byrne, Elizabeth,Pastor, Gary,Pellas, Theodore,Quadros, Elizabeth,Reel, Noela,Roland, Dennis M.,Sakane, Yumi,Singh, Hem,Skiles, Jerry,Somers, Joseph,Toscano, Karen,Wigg, Andrew,Zhou, Siyuan,Zhu, Lijuan,Shieh, Wen-Chung,Xue, Song,McQuire, Leslie W.. "Discovery of Potent, Selective, and Orally Active Carboxylic Acid Based Inhibitors of Matrix Metalloproteinase-13". supporting information; experimental part. p. 3523 - 3538. Retrieved 2010/03/30.
• 2、 -. "N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin". Page column 107. . Retrieved 2010/01/30.