[(E)-1-Dimethylamino-2-(4-nitro-phenyl)-vinyl]-phosphonic acid diethyl ester

Base Information

• Chemical Name: [(E)-1-Dimethylamino-2-(4-nitro-phenyl)-vinyl]-phosphonic acid diethyl ester
• CAS No.: 79054-43-6
• Molecular Formula: C₁₄H₂₁N₂O₅P
• Molecular Weight: 328.305

Synonyms:[(E)-1-Dimethylamino-2-(4-nitro-phenyl)-vinyl]-phosphonic acid diethyl ester

Chemical Property of [(E)-1-Dimethylamino-2-(4-nitro-phenyl)-vinyl]-phosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

SDS file from LookChem

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Technology Process of [(E)-1-Dimethylamino-2-(4-nitro-phenyl)-vinyl]-phosphonic acid diethyl ester

There total 2 articles about [(E)-1-Dimethylamino-2-(4-nitro-phenyl)-vinyl]-phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

diethyl trimethylsilyl-N,N-dimethylaminomethylphosphonate (1006713-83-2) + 4-nitrobenzaldehdye (555-16-8) → [(E)-1-Dimethylamino-2-(4-nitro-phenyl)-vinyl]-phosphonic acid diethyl ester (79054-43-6)

Guidance literature:

diethyl trimethylsilyl-N,N-dimethylaminomethylphosphonate; With sec.-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.666667h;

4-nitrobenzaldehdye; In tetrahydrofuran; at -78 - 25 ℃; Further stages.;

DOI:10.1016/j.tetlet.2007.11.066

Reference yield:

tetraethyl dimethylaminomethylenediphosphonate (18855-52-2) + 4-nitrobenzaldehdye (555-16-8) → [(E)-1-Dimethylamino-2-(4-nitro-phenyl)-vinyl]-phosphonic acid diethyl ester (79054-43-6)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) dioxane, room temperature, 2.) heating;

DOI:10.1016/S0040-4020(01)92055-1

Reference yield: 98.0%

[(E)-1-Dimethylamino-2-(4-nitro-phenyl)-vinyl]-phosphonic acid diethyl ester (79054-43-6) → 4-nitrobenzeneacetic acid (104-03-0)

Guidance literature:

With hydrogen bromide; at 100 ℃; for 0.166667h;

DOI:10.1016/j.tetlet.2007.11.066

upstream raw materials:

tetraethyl dimethylaminomethylenediphosphonate

4-nitrobenzaldehdye

diethyl trimethylsilyl-N,N-dimethylaminomethylphosphonate

Downstream raw materials:

[(E)-1-Hydroxy-2-(4-nitro-phenyl)-vinyl]-phosphonic acid diethyl ester

4-nitrobenzeneacetic acid

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