4-(N-PIPERIDINO)-THIOSEMICARBAZIDE

Base Information

• Chemical Name: 4-(N-PIPERIDINO)-THIOSEMICARBAZIDE
• CAS No.: 91469-16-8
• Molecular Formula: C6H14N4S
• Molecular Weight: 174.27
• Hs Code.: 2933399090
• Mol file: 91469-16-8.mol

Synonyms:Semicarbazide,4-piperidino-3-thio- (7CI);

Chemical Property of 4-(N-PIPERIDINO)-THIOSEMICARBAZIDE

Chemical Property:

• Vapor Pressure: 0.00381mmHg at 25°C
• Melting Point: 170-171 °C
• Refractive Index: 1.624
• Boiling Point: 280.3 °C at 760 mmHg
• PKA: 11.23±0.70(Predicted)
• Flash Point: 123.3 °C
• PSA: 85.41000
• Density: 1.23 g/cm³
• LogP: 1.14510

Purity/Quality:

99%min ^*data from raw suppliers

4-(N-PIPERIDINO)-THIOSEMICARBAZIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(N-PIPERIDINO)-THIOSEMICARBAZIDE

There total 4 articles about 4-(N-PIPERIDINO)-THIOSEMICARBAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

C11H16N6OS (717876-06-7) → 1-piperidinothiosemicarbazide (91469-16-8)

Guidance literature:

With sodium hydroxide; for 2h; Heating;

DOI:10.1080/10426500500272327

Reference yield:

piperidin-1-yl-dithiocarbamic acid methyl ester (39219-01-7) → 1-piperidinothiosemicarbazide (91469-16-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Reflux;

DOI:10.1002/jhet.1640

Reference yield:

1-Aminopiperidine (2213-43-6) → 1-piperidinothiosemicarbazide (91469-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / ethanol / 0.25 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: hydrazine hydrate / ethanol / 2 h / Reflux

With hydrazine hydrate; triethylamine; In ethanol;

DOI:10.1002/jhet.1640

upstream raw materials:

C₁₁H₁₆N₆OS

piperidin-1-yl-dithiocarbamic acid methyl ester

1-Aminopiperidine

Downstream raw materials:

5-(4-chlorophenyl)-N-(piperidin-1-yl)-1,3,4-thiadiazol-2-amine

5-(4-chloro-phenyl)-4-piperidin-1-yl-2,4-dihydro-[1,2,4]triazole-3-thione

Refernces

• 1、 Foks, Henryk,Pancechowska-Ksepko, Danuta,Gobis, Katarzyna. "Synthesis and characterization of novel N-alkylamine- and N-cycloalkylamine-derived 2-benzoyl-N-aminohydrazinecarbothioamides, 1,3,4-thiadiazoles and 1,2,4-triazole-5(4H)thiones". . p. 507 - 512. Retrieved 2014/04/17.