(+)-(S)-γ-(3-chlorophenyl)-γ-butyrolactone

Base Information

Chemical Name:(+)-(S)-γ-(3-chlorophenyl)-γ-butyrolactone
CAS No.:1270301-96-6
Molecular Formula:C₁₀H₉ClO₂
Molecular Weight:196.633
Hs Code.:

Synonyms:(+)-(S)-γ-(3-chlorophenyl)-γ-butyrolactone

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Chemical Property of (+)-(S)-γ-(3-chlorophenyl)-γ-butyrolactone

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Technology Process of (+)-(S)-γ-(3-chlorophenyl)-γ-butyrolactone

There total 4 articles about (+)-(S)-γ-(3-chlorophenyl)-γ-butyrolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 62903-14-4
4-(3-chlorophenyl)-4-oxobutyric acid

: 1270301-96-6
(+)-(S)-γ-(3-chlorophenyl)-γ-butyrolactone

Guidance literature:: With (R,R)-(?)-2,3-bis(t-butylmethylphosphino)quinoxaline; hydrogen; palladium diacetate; zinc trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 70 ℃; for 32h; enantioselective reaction;
DOI:10.1002/asia.202100244

Reference yield:

: 1429482-75-6
4-oxo-4-(3-chlorophenyl)-1-butanol

: 1270299-75-6
(+)-(R)-γ-(3-chlorophenyl)-γ-butyrolactone

: 1270301-96-6
(+)-(S)-γ-(3-chlorophenyl)-γ-butyrolactone

Guidance literature:: With C₃₁H₃₄N₂O₂RuS; sodium t-butanolate; In ethyl acetate; isopropyl alcohol; acetone; at 22 ℃; for 24h; Reagent/catalyst; Overall yield = 96 %; enantioselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1021/ja4021974

Reference yield:

: 618-46-2
m-Chlorobenzoyl chloride

: 1270299-75-6
(+)-(R)-γ-(3-chlorophenyl)-γ-butyrolactone

: 1270301-96-6
(+)-(S)-γ-(3-chlorophenyl)-γ-butyrolactone

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane / 1.5 h / -78 °C / Cooling with acetone-dry ice

1.2: Cooling with acetone-dry ice

2.1: hydrogenchloride / tetrahydrofuran; water; methanol / Reflux

3.1: C₃₁H₃₄N₂O₂RuS; sodium t-butanolate / ethyl acetate; acetone; isopropyl alcohol / 24 h / 22 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; C₃₁H₃₄N₂O₂RuS; sodium t-butanolate; lithium diisopropyl amide; In tetrahydrofuran; methanol; n-heptane; water; ethyl acetate; isopropyl alcohol; acetone; 3.1: |Noyori Asymmetric Hydrogenation;
DOI:10.1021/ja4021974