2,2,2-Trichloro-N-[(1R,2S)-2-hydroxy-1-((S)-hydroxy-pyridin-3-yl-methyl)-cyclohexyl]-acetamide

Base Information

Chemical Name:2,2,2-Trichloro-N-[(1R,2S)-2-hydroxy-1-((S)-hydroxy-pyridin-3-yl-methyl)-cyclohexyl]-acetamide
CAS No.:142968-28-3
Molecular Formula:C₁₄H₁₇Cl₃N₂O₃
Molecular Weight:367.66
Hs Code.:

Synonyms:2,2,2-Trichloro-N-[(1R,2S)-2-hydroxy-1-((S)-hydroxy-pyridin-3-yl-methyl)-cyclohexyl]-acetamide

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Chemical Property of 2,2,2-Trichloro-N-[(1R,2S)-2-hydroxy-1-((S)-hydroxy-pyridin-3-yl-methyl)-cyclohexyl]-acetamide

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Technology Process of 2,2,2-Trichloro-N-[(1R,2S)-2-hydroxy-1-((S)-hydroxy-pyridin-3-yl-methyl)-cyclohexyl]-acetamide

There total 5 articles about 2,2,2-Trichloro-N-[(1R,2S)-2-hydroxy-1-((S)-hydroxy-pyridin-3-yl-methyl)-cyclohexyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 142968-27-2
2,2,2-Trichloro-acetimidic acid (2R,3R,4R)-2-pyridin-3-yl-1-oxa-spiro[2.5]oct-4-yl ester

: 142968-28-3
2,2,2-Trichloro-N-[(1R,2S)-2-hydroxy-1-((S)-hydroxy-pyridin-3-yl-methyl)-cyclohexyl]-acetamide

Guidance literature:: With boron trifluoride diethyl etherate; In various solvent(s); at 0 ℃;
DOI:10.1016/S0040-4039(00)79585-2

Reference yield:

: 142968-16-9
2-[1-Pyridin-3-yl-meth-(E)-ylidene]-cyclohexanone

: 142968-28-3
2,2,2-Trichloro-N-[(1R,2S)-2-hydroxy-1-((S)-hydroxy-pyridin-3-yl-methyl)-cyclohexyl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / H₂O₂, NaOH / methanol / 0 - 5 °C

2: 95 percent / KBH₄ / ethanol; CH₂Cl₂ / -15 °C

3: 1) NaH / THF, 0 deg C

4: 90 percent / BF₃*OEt₂ / various solvent(s) / 0 °C

With sodium hydroxide; potassium borohydride; boron trifluoride diethyl etherate; dihydrogen peroxide; sodium hydride; In methanol; ethanol; dichloromethane;
DOI:10.1016/S0040-4039(00)79585-2

Reference yield:

: 142968-18-1
(2S,3S,4S)-2-Pyridin-3-yl-1-oxa-spiro[2.5]octan-4-ol

: 142968-28-3
2,2,2-Trichloro-N-[(1R,2S)-2-hydroxy-1-((S)-hydroxy-pyridin-3-yl-methyl)-cyclohexyl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH / THF, 0 deg C

2: 90 percent / BF₃*OEt₂ / various solvent(s) / 0 °C

With boron trifluoride diethyl etherate; sodium hydride; In various solvent(s);
DOI:10.1016/S0040-4039(00)79585-2