2-Benzoyl-5-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxymethyl)-6-methylene-oct-7-enoic acid methyl ester

Base Information

Chemical Name:2-Benzoyl-5-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxymethyl)-6-methylene-oct-7-enoic acid methyl ester
CAS No.:202813-72-7
Molecular Formula:C₃₂H₄₄O₆Si
Molecular Weight:552.783
Hs Code.:

Synonyms:2-Benzoyl-5-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxymethyl)-6-methylene-oct-7-enoic acid methyl ester

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Chemical Property of 2-Benzoyl-5-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxymethyl)-6-methylene-oct-7-enoic acid methyl ester

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Technology Process of 2-Benzoyl-5-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxymethyl)-6-methylene-oct-7-enoic acid methyl ester

There total 9 articles about 2-Benzoyl-5-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxymethyl)-6-methylene-oct-7-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 93-58-3,5705-52-2,80226-58-0
benzoic acid methyl ester

: 202813-57-8
5-(tert-Butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxymethyl)-6-methylene-oct-7-enoic acid methyl ester

: 202813-72-7
2-Benzoyl-5-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxymethyl)-6-methylene-oct-7-enoic acid methyl ester

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; at -78 - 23 ℃; for 4h;
DOI:10.1002/anie.199728211

Reference yield:

: 73255-29-5
3-(hydroxymethyl)but-3-en-2-one

: 202813-72-7
2-Benzoyl-5-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxymethyl)-6-methylene-oct-7-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 78 percent / CSA / CH₂Cl₂ / 3 h / 23 °C

2: 60 percent / NaHMDS / tetrahydrofuran / 1 h / -40 °C

3: 1.) Me₃SnSnMe₃, LiCl, 2.) n-BuLi / 1.) Pd(PPh₃)4 / 1.) THF, 60 deg C, 8 h, 2.) THF, -78 deg C, 20 min; -78 to 0 deg C, 1 h

4: 94 percent / imidazole / dimethylformamide / 4 h / 50 °C

5: 91 percent / CSA / methanol; CH₂Cl₂ / 0.33 h / 0 °C

6: 1.) DMSO, (COCl)2, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 30 min

7: aq. NaClO₂, NaH₂PO₄, 2-methyl-2-butene / tetrahydrofuran; 2-methyl-propan-2-ol / 1 h / 0 °C

8: diethyl ether / 0.08 h / 23 °C

9: 93 percent / KHMDS / tetrahydrofuran / 4 h / -78 - 23 °C

With 1H-imidazole; sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; oxalyl dichloride; camphor-10-sulfonic acid; hexamethyldistannane; sodium hexamethyldisilazane; potassium hexamethylsilazane; dimethyl sulfoxide; triethylamine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/anie.199728211

Reference yield:

: 202813-54-5
3-(((4-methoxybenzyl)oxy)methyl)but-3-en-2-one

: 202813-72-7
2-Benzoyl-5-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxymethyl)-6-methylene-oct-7-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 60 percent / NaHMDS / tetrahydrofuran / 1 h / -40 °C

2: 1.) Me₃SnSnMe₃, LiCl, 2.) n-BuLi / 1.) Pd(PPh₃)4 / 1.) THF, 60 deg C, 8 h, 2.) THF, -78 deg C, 20 min; -78 to 0 deg C, 1 h

3: 94 percent / imidazole / dimethylformamide / 4 h / 50 °C

4: 91 percent / CSA / methanol; CH₂Cl₂ / 0.33 h / 0 °C

5: 1.) DMSO, (COCl)2, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 30 min

6: aq. NaClO₂, NaH₂PO₄, 2-methyl-2-butene / tetrahydrofuran; 2-methyl-propan-2-ol / 1 h / 0 °C

7: diethyl ether / 0.08 h / 23 °C

8: 93 percent / KHMDS / tetrahydrofuran / 4 h / -78 - 23 °C

With 1H-imidazole; sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; oxalyl dichloride; camphor-10-sulfonic acid; hexamethyldistannane; sodium hexamethyldisilazane; potassium hexamethylsilazane; dimethyl sulfoxide; triethylamine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/anie.199728211