6-[1-(2-chloro-6-fluorophenyl)ethyl]-5-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Base Information

Chemical Name:6-[1-(2-chloro-6-fluorophenyl)ethyl]-5-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
CAS No.:1613668-88-4
Molecular Formula:C₁₃H₁₂ClFN₂OS
Molecular Weight:298.768
Hs Code.:

Synonyms:6-[1-(2-chloro-6-fluorophenyl)ethyl]-5-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

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Chemical Property of 6-[1-(2-chloro-6-fluorophenyl)ethyl]-5-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

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Technology Process of 6-[1-(2-chloro-6-fluorophenyl)ethyl]-5-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

There total 4 articles about 6-[1-(2-chloro-6-fluorophenyl)ethyl]-5-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1083172-73-9
C₉H₈ClFO₂

: 1613668-88-4
6-[1-(2-chloro-6-fluorophenyl)ethyl]-5-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetonitrile / 0.25 h / 20 °C

2.1: triethylamine; magnesium chloride / acetonitrile / 2 h / 20 °C

2.2: 20 °C / Reflux

2.3: 0.25 h / 25 °C

3.1: sodium / ethanol / Reflux

With sodium; triethylamine; magnesium chloride; In ethanol; acetonitrile;
DOI:10.1021/jm500284x

Reference yield:

: 37777-76-7
2-chloro-6-fluoro-phenylacetic acid

: 1613668-88-4
6-[1-(2-chloro-6-fluorophenyl)ethyl]-5-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; diethylamine / hexane; tetrahydrofuran / 0.5 h / -78 - 0 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: acetonitrile / 0.25 h / 20 °C

3.1: triethylamine; magnesium chloride / acetonitrile / 2 h / 20 °C

3.2: 20 °C / Reflux

3.3: 0.25 h / 25 °C

4.1: sodium / ethanol / Reflux

With n-butyllithium; sodium; diethylamine; triethylamine; magnesium chloride; In tetrahydrofuran; ethanol; hexane; acetonitrile;
DOI:10.1021/jm500284x

Reference yield:

: 1613668-81-7
C₁₂H₁₀ClFN₂O

: 1613668-88-4
6-[1-(2-chloro-6-fluorophenyl)ethyl]-5-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; magnesium chloride / acetonitrile / 2 h / 20 °C

1.2: 20 °C / Reflux

1.3: 0.25 h / 25 °C

2.1: sodium / ethanol / Reflux

With sodium; triethylamine; magnesium chloride; In ethanol; acetonitrile;
DOI:10.1021/jm500284x