methyl 21-(4-acetoxymethylphenyl)henicosanoate

Base Information

Chemical Name:methyl 21-(4-acetoxymethylphenyl)henicosanoate
CAS No.:128368-87-6
Molecular Formula:C₃₁H₅₂O₄
Molecular Weight:488.751
Hs Code.:

Synonyms:methyl 21-(4-acetoxymethylphenyl)henicosanoate

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Chemical Property of methyl 21-(4-acetoxymethylphenyl)henicosanoate

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Technology Process of methyl 21-(4-acetoxymethylphenyl)henicosanoate

There total 12 articles about methyl 21-(4-acetoxymethylphenyl)henicosanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 128368-86-5
21-(4-acetoxymethylphenyl)henicosanic acid

: 128368-87-6
methyl 21-(4-acetoxymethylphenyl)henicosanoate

Guidance literature:: In diethyl ether;
DOI:10.1039/c39900000031

Reference yield:

: 7735-43-5
1,20-eicosanediol

: 128368-87-6
methyl 21-(4-acetoxymethylphenyl)henicosanoate

Guidance literature:: Multi-step reaction with 8 steps

1: 49 percent / 48percent aq. HBr / petroleum ether / 24 h / Heating

2: PPTS / CH₂Cl₂ / 20 h / Ambient temperature

3: 1) lithium diisopropylamide / 1) THF, 0 deg C, 30 min, 2) THF, 30 min

4: 67 percent / BH₃-Me₂S / tetrahydrofuran / 20 h / Ambient temperature

5: 85 percent / 4-(dimethylamino)pyridine, pyridine / CH₂Cl₂ / 20 h / Ambient temperature

6: 95 percent / PPTS / ethanol / 1 h / Heating

7: 87 percent / Jones reagent / acetone

8: 78 percent / diethyl ether; tetrahydrofuran / 0 °C

With pyridine; dmap; jones reagent; dimethylsulfide borane complex; hydrogen bromide; pyridinium p-toluenesulfonate; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetone; Petroleum ether;
DOI:10.1016/S0040-4020(01)86422-X

Reference yield:

: 128368-84-3
4-(21-tetrahydropyranyloxyhenicosyl)benzyl alcohol

: 128368-87-6
methyl 21-(4-acetoxymethylphenyl)henicosanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / 4-(dimethylamino)pyridine, pyridine / CH₂Cl₂ / 20 h / Ambient temperature

2: 95 percent / PPTS / ethanol / 1 h / Heating

3: 87 percent / Jones reagent / acetone

4: 78 percent / diethyl ether; tetrahydrofuran / 0 °C

With pyridine; dmap; jones reagent; pyridinium p-toluenesulfonate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetone;
DOI:10.1016/S0040-4020(01)86422-X