2-cyclopropyl-4-ethyl-5-fluoro-5-(furan-2-yl)-4-phenyl-4,5-dihydrooxazole

Base Information

Chemical Name:2-cyclopropyl-4-ethyl-5-fluoro-5-(furan-2-yl)-4-phenyl-4,5-dihydrooxazole
CAS No.:1260435-50-4
Molecular Formula:C₁₈H₁₈FNO₂
Molecular Weight:299.345
Hs Code.:

Synonyms:2-cyclopropyl-4-ethyl-5-fluoro-5-(furan-2-yl)-4-phenyl-4,5-dihydrooxazole

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Chemical Property of 2-cyclopropyl-4-ethyl-5-fluoro-5-(furan-2-yl)-4-phenyl-4,5-dihydrooxazole

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Technology Process of 2-cyclopropyl-4-ethyl-5-fluoro-5-(furan-2-yl)-4-phenyl-4,5-dihydrooxazole

There total 4 articles about 2-cyclopropyl-4-ethyl-5-fluoro-5-(furan-2-yl)-4-phenyl-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1260435-40-2
N-(1-(furan-2-yl)-1-oxo-2-phenylbutan-2-yl)cyclopropanecarboxamide

: 1260435-50-4
2-cyclopropyl-4-ethyl-5-fluoro-5-(furan-2-yl)-4-phenyl-4,5-dihydrooxazole

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 60 ℃; for 2h; optical yield given as %de; Inert atmosphere; Microwave irradiation;
DOI:10.1021/ol102454e

Reference yield:

: 1260435-60-6
2-cyclopropyl-4-ethyl-4-phenyloxazol-5(4H)-one

: 1260435-50-4
2-cyclopropyl-4-ethyl-5-fluoro-5-(furan-2-yl)-4-phenyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0 - 20 °C / Inert atmosphere

2.2: 1.5 h / -78 - 20 °C / Inert atmosphere

3.1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / 60 °C / Inert atmosphere; Microwave irradiation

With pyridine; n-butyllithium; diethylamino-sulfur trifluoride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol102454e

Reference yield:

: 1260435-61-7
N-(1-(methoxy(methyl)amino)-1-oxo-2-phenylbutan-2-yl)cyclopropanecarboxamide

: 1260435-50-4
2-cyclopropyl-4-ethyl-5-fluoro-5-(furan-2-yl)-4-phenyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0 - 20 °C / Inert atmosphere

1.2: 1.5 h / -78 - 20 °C / Inert atmosphere

2.1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / 60 °C / Inert atmosphere; Microwave irradiation

With n-butyllithium; diethylamino-sulfur trifluoride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol102454e