1-(4-methoxy-dibenzofuran-1-yl)-4-oxo-cyclohexane carbonitrile

Base Information

• Chemical Name: 1-(4-methoxy-dibenzofuran-1-yl)-4-oxo-cyclohexane carbonitrile
• CAS No.: 1012335-47-5
• Molecular Formula: C₂₀H₁₇NO₃
• Molecular Weight: 319.36
• Mol file: 1012335-47-5.mol

Synonyms:1-(4-methoxy-dibenzofuran-1-yl)-4-oxo-cyclohexane carbonitrile

Chemical Property of 1-(4-methoxy-dibenzofuran-1-yl)-4-oxo-cyclohexane carbonitrile

Chemical Property:

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Technology Process of 1-(4-methoxy-dibenzofuran-1-yl)-4-oxo-cyclohexane carbonitrile

There total 1 articles about 1-(4-methoxy-dibenzofuran-1-yl)-4-oxo-cyclohexane carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

5-cyano-5-(4-methoxy-dibenzofuran-1-yl)-2-oxo-cyclohexane carboxylic acid methyl ester (1012335-45-3) → 1-(4-methoxy-dibenzofuran-1-yl)-4-oxo-cyclohexane carbonitrile (1012335-47-5)

Guidance literature:

With water; sodium chloride; In dimethyl sulfoxide; at 20 - 140 ℃; for 5h;

Reference yield: 89.0%

1-(4-methoxy-dibenzofuran-1-yl)-4-oxo-cyclohexane carbonitrile (1012335-47-5) + (R)-1-phenyl-ethyl-amine (3886-69-9) → 1-(4-methoxy-dibenzofuran-1-yl)-4-((R)-1-phenyl-ethylamino)-cyclohexanecarbonitrile (1013120-97-2)

Guidance literature:

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 0 - 20 ℃; for 2.25h;

Reference yield: 86.5%

1-(4-methoxy-dibenzofuran-1-yl)-4-oxo-cyclohexane carbonitrile (1012335-47-5) → C20H18N2O3

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; at 85 - 90 ℃; for 3h; Product distribution / selectivity;

upstream raw materials:

5-cyano-5-(4-methoxy-dibenzofuran-1-yl)-2-oxo-cyclohexane carboxylic acid methyl ester

Downstream raw materials:

1-(4-methoxy-dibenzofuran-1-yl)-4-((R)-1-phenyl-ethylamino)-cyclohexanecarbonitrile

(3E)-3-[(dimethylamino)methylene]-1-(4-methoxydibenzo[b,d]furan-1-yl)-4-oxocyclohexanecarbonitrile

Refernces