5-[(3-NITROPHENYL)METHYLENE]-1,3-THIAZOLANE-2,4-DIONE

Base Information

• Chemical Name: 5-[(3-NITROPHENYL)METHYLENE]-1,3-THIAZOLANE-2,4-DIONE
• CAS No.: 24044-52-8
• Molecular Formula: C10H6N2O4S
• Molecular Weight: 250.235
• Hs Code.: 2934999090
• Mol file: 24044-52-8.mol

Synonyms:5-(3-Nitrobenzylidene)thiazolidine-2,4-dione;2,4-Thiazolidinedione,5-(m-nitrobenzylidene)- (6CI,8CI);

Chemical Property of 5-[(3-NITROPHENYL)METHYLENE]-1,3-THIAZOLANE-2,4-DIONE

Chemical Property:

• Melting Point: 185-187 °C
• Refractive Index: 1.732
• PKA: 7.14±0.20(Predicted)
• PSA: 117.29000
• Density: 1.595 g/cm³
• LogP: 2.77070

Purity/Quality:

97% ^*data from raw suppliers

5-[(3-Nitrophenyl)methylene]-1,3-thiazolidine-2,4-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-[(3-NITROPHENYL)METHYLENE]-1,3-THIAZOLANE-2,4-DIONE

There total 6 articles about 5-[(3-NITROPHENYL)METHYLENE]-1,3-THIAZOLANE-2,4-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

thiazoline-2,4-dione (2295-31-0) + 3-nitro-benzaldehyde (99-61-6) → 5-(3-nitrobenzylidene)-1,3-thiazolidine-2,4-dione (24044-52-8,1064365-91-8)

Guidance literature:

With methylamine; In acetic acid;

Reference yield: 53.0%

5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione (123043-88-9,33458-26-3) + 3-nitro-benzaldehyde (99-61-6) + chloroacetic acid (79-11-8) → 5-(3-nitrobenzylidene)-1,3-thiazolidine-2,4-dione (24044-52-8,1064365-91-8)

Guidance literature:

5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione; 3-nitro-benzaldehyde; chloroacetic acid; With sodium acetate; In acetic acid; for 18h; Reflux;

With acetic acid; at 20 ℃; for 24h;

DOI:10.1002/jhet.323

Reference yield: 53.0%

ethyl 5-phenyl-2-(3-nitrophenylmethylene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate (292871-32-0) → 5-(3-nitrobenzylidene)-1,3-thiazolidine-2,4-dione (24044-52-8,1064365-91-8)

Guidance literature:

With water; In acetic acid; for 18h;

DOI:10.1002/jhet.323

upstream raw materials:

thiazoline-2,4-dione

3-nitro-benzaldehyde

thiocyanatoacetic acid, Na-salt

ethyl 5-phenyl-2-(3-nitrophenylmethylene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

Downstream raw materials:

5-(3-nitro-benzylidene)-4-thioxo-thiazolidin-2-one

3-(2-biphenyl-4-yl-2-oxo-ethyl)-5-(3-nitro-benzylidene)-thiazolidine-2,4-dione

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