2-methyl-2-(4-(6-(pyridin-3-yl)-3-nitroquinolin-4-ylamino)phenyl)-2-methylpropanenitrile

Base Information

Chemical Name:2-methyl-2-(4-(6-(pyridin-3-yl)-3-nitroquinolin-4-ylamino)phenyl)-2-methylpropanenitrile
CAS No.:1201646-81-2
Molecular Formula:C₂₄H₁₉N₅O₂
Molecular Weight:409.447
Hs Code.:

Synonyms:2-methyl-2-(4-(6-(pyridin-3-yl)-3-nitroquinolin-4-ylamino)phenyl)-2-methylpropanenitrile

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Chemical Property of 2-methyl-2-(4-(6-(pyridin-3-yl)-3-nitroquinolin-4-ylamino)phenyl)-2-methylpropanenitrile

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Technology Process of 2-methyl-2-(4-(6-(pyridin-3-yl)-3-nitroquinolin-4-ylamino)phenyl)-2-methylpropanenitrile

There total 5 articles about 2-methyl-2-(4-(6-(pyridin-3-yl)-3-nitroquinolin-4-ylamino)phenyl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 915019-51-1
2-(4-((6-bromo-3-nitroquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile

: 1692-25-7
3-pyridylboronic acid

: 1201646-81-2
2-methyl-2-(4-(6-(pyridin-3-yl)-3-nitroquinolin-4-ylamino)phenyl)-2-methylpropanenitrile

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 90 ℃; Inert atmosphere;

Reference yield:

: 1201643-75-5
(E)-5-bromo-2-((2-nitrovinyl)amino)benzoic acid

: 1201646-81-2
2-methyl-2-(4-(6-(pyridin-3-yl)-3-nitroquinolin-4-ylamino)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / acetic anhydride / 1.5 h / 120 °C

2: N-ethyl-N,N-diisopropylamine; trichlorophosphate / acetonitrile / 2 h / 0 - 100 °C

3: acetic acid / 0.5 h / 25 °C

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 90 °C / Inert atmosphere

With potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; acetic anhydride; acetic acid; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 723281-72-9
6-bromo-4-chloro-3-nitroquinoline

: 1201646-81-2
2-methyl-2-(4-(6-(pyridin-3-yl)-3-nitroquinolin-4-ylamino)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 0.5 h / 25 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 90 °C / Inert atmosphere

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; acetic acid; N,N-dimethyl-formamide;