1'-(thymin-1-yl)-2',3'-(dideoxydidehydro)-5'-(O-benzyl)-β-D-apio-D-furanose

Base Information

Chemical Name:1'-(thymin-1-yl)-2',3'-(dideoxydidehydro)-5'-(O-benzyl)-β-D-apio-D-furanose
CAS No.:1610459-86-3
Molecular Formula:C₁₇H₁₈N₂O₄
Molecular Weight:314.341
Hs Code.:

Synonyms:1'-(thymin-1-yl)-2',3'-(dideoxydidehydro)-5'-(O-benzyl)-β-D-apio-D-furanose

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Chemical Property of 1'-(thymin-1-yl)-2',3'-(dideoxydidehydro)-5'-(O-benzyl)-β-D-apio-D-furanose

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Technology Process of 1'-(thymin-1-yl)-2',3'-(dideoxydidehydro)-5'-(O-benzyl)-β-D-apio-D-furanose

There total 5 articles about 1'-(thymin-1-yl)-2',3'-(dideoxydidehydro)-5'-(O-benzyl)-β-D-apio-D-furanose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1610459-84-1
1'-(thymin-1-yl)-2',3'-(O-thiocarbonyl)-5'-(O-benzyl)-β-D-apio-D-furanose

: 1610459-86-3
1'-(thymin-1-yl)-2',3'-(dideoxydidehydro)-5'-(O-benzyl)-β-D-apio-D-furanose

Guidance literature:: With phosphorous acid trimethyl ester; at 120 ℃; for 6h; Inert atmosphere;
DOI:10.1021/jo500659e

Reference yield:

: 65-71-4,28806-14-6,691841-57-3
thymin

: 1610459-86-3
1'-(thymin-1-yl)-2',3'-(dideoxydidehydro)-5'-(O-benzyl)-β-D-apio-D-furanose

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane; pyridine / Reflux; Inert atmosphere

1.2: 4 h / 25 °C / Inert atmosphere

2.1: ammonia / methanol / 25 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide / 1.5 h / 80 °C / Inert atmosphere

4.1: phosphorous acid trimethyl ester / 6 h / 120 °C / Inert atmosphere

With pyridine; chloro-trimethyl-silane; ammonia; 1,1,1,3,3,3-hexamethyl-disilazane; phosphorous acid trimethyl ester; In methanol; N,N-dimethyl-formamide; 1.2: |Vorbrueggen Nucleoside Synthesis;
DOI:10.1021/jo500659e

Reference yield:

: 245432-69-3
1,2,3-tri-O-acetyl-3-C-(benzyloxymethyl)-α/β-D-erythrofuranoside

: 1610459-86-3
1'-(thymin-1-yl)-2',3'-(dideoxydidehydro)-5'-(O-benzyl)-β-D-apio-D-furanose

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane; pyridine / Reflux; Inert atmosphere

1.2: 4 h / 25 °C / Inert atmosphere

2.1: ammonia / methanol / 25 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide / 1.5 h / 80 °C / Inert atmosphere

4.1: phosphorous acid trimethyl ester / 6 h / 120 °C / Inert atmosphere

With pyridine; chloro-trimethyl-silane; ammonia; 1,1,1,3,3,3-hexamethyl-disilazane; phosphorous acid trimethyl ester; In methanol; N,N-dimethyl-formamide; 1.2: |Vorbrueggen Nucleoside Synthesis;
DOI:10.1021/jo500659e