Technology Process of 1'-(thymin-1-yl)-2',3'-(dideoxydidehydro)-5'-(O-benzyl)-β-D-apio-D-furanose
There total 5 articles about 1'-(thymin-1-yl)-2',3'-(dideoxydidehydro)-5'-(O-benzyl)-β-D-apio-D-furanose which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
phosphorous acid trimethyl ester;
at 120 ℃;
for 6h;
Inert atmosphere;
DOI:10.1021/jo500659e
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane; pyridine / Reflux; Inert atmosphere
1.2: 4 h / 25 °C / Inert atmosphere
2.1: ammonia / methanol / 25 °C / Inert atmosphere
3.1: N,N-dimethyl-formamide / 1.5 h / 80 °C / Inert atmosphere
4.1: phosphorous acid trimethyl ester / 6 h / 120 °C / Inert atmosphere
With
pyridine; chloro-trimethyl-silane; ammonia; 1,1,1,3,3,3-hexamethyl-disilazane; phosphorous acid trimethyl ester;
In
methanol; N,N-dimethyl-formamide;
1.2: |Vorbrueggen Nucleoside Synthesis;
DOI:10.1021/jo500659e
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane; pyridine / Reflux; Inert atmosphere
1.2: 4 h / 25 °C / Inert atmosphere
2.1: ammonia / methanol / 25 °C / Inert atmosphere
3.1: N,N-dimethyl-formamide / 1.5 h / 80 °C / Inert atmosphere
4.1: phosphorous acid trimethyl ester / 6 h / 120 °C / Inert atmosphere
With
pyridine; chloro-trimethyl-silane; ammonia; 1,1,1,3,3,3-hexamethyl-disilazane; phosphorous acid trimethyl ester;
In
methanol; N,N-dimethyl-formamide;
1.2: |Vorbrueggen Nucleoside Synthesis;
DOI:10.1021/jo500659e
