ethyl (6R,9S)-6-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)benzyl)-9-isopropyl-2,2-dimethyl-4,7-dioxo-3,11-dioxa-5,8-diazatetradecan-14-oate

Base Information

Chemical Name:ethyl (6R,9S)-6-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)benzyl)-9-isopropyl-2,2-dimethyl-4,7-dioxo-3,11-dioxa-5,8-diazatetradecan-14-oate
CAS No.:1198186-42-3
Molecular Formula:C₃₉H₄₉N₃O₈
Molecular Weight:687.833
Hs Code.:

Synonyms:ethyl (6R,9S)-6-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)benzyl)-9-isopropyl-2,2-dimethyl-4,7-dioxo-3,11-dioxa-5,8-diazatetradecan-14-oate

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Chemical Property of ethyl (6R,9S)-6-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)benzyl)-9-isopropyl-2,2-dimethyl-4,7-dioxo-3,11-dioxa-5,8-diazatetradecan-14-oate

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Technology Process of ethyl (6R,9S)-6-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)benzyl)-9-isopropyl-2,2-dimethyl-4,7-dioxo-3,11-dioxa-5,8-diazatetradecan-14-oate

There total 5 articles about ethyl (6R,9S)-6-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)benzyl)-9-isopropyl-2,2-dimethyl-4,7-dioxo-3,11-dioxa-5,8-diazatetradecan-14-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: ethyl (S)-3-(2-amino-3-methylbutoxy)propanoate

: 114346-31-5,173054-11-0
(R)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid

: 1198186-42-3
ethyl (6R,9S)-6-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)benzyl)-9-isopropyl-2,2-dimethyl-4,7-dioxo-3,11-dioxa-5,8-diazatetradecan-14-oate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.0c01500

Reference yield:

: 1198186-37-6
ethyl 3-((S)-2-amino-3-methylbutoxy)propionate trifluoroacetate

: 114346-31-5,173054-11-0
(R)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid

: 1198186-42-3
ethyl (6R,9S)-6-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)benzyl)-9-isopropyl-2,2-dimethyl-4,7-dioxo-3,11-dioxa-5,8-diazatetradecan-14-oate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1198186-34-3
Ethyl 3-((S)-2-tert-butoxycarbonylamino-3-methylbutoxy)propionate

: 1198186-42-3
ethyl (6R,9S)-6-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)benzyl)-9-isopropyl-2,2-dimethyl-4,7-dioxo-3,11-dioxa-5,8-diazatetradecan-14-oate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 2 h / 20 °C

2: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide;