ethyl (R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoate

Base Information

• Chemical Name: ethyl (R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoate
• CAS No.: 139657-26-4
• Molecular Formula: C₃₇H₄₇N₃O₅
• Molecular Weight: 613.797

Synonyms:ethyl (R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoate

Chemical Property of ethyl (R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoate

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Technology Process of ethyl (R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoate

There total 2 articles about ethyl (R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

ethyl 3-(chloroformyl)propionate (14794-31-1,97900-84-0) + tricyclo<3.3.1.13,7>dec-2-yl <1-(1H-indol-3-ylmethyl)-1-methyl-2-<(2-phenylethyl)amino>ethyl>carbamate (139657-24-2) → ethyl (R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoate (139657-26-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.333333h;

DOI:10.1021/jm00086a017

Reference yield:

tricyclo[3.3.1.13,7]dec-2-yl (R)-{1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl}carbamate (130406-43-8) → ethyl (R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoate (139657-26-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 14 percent / lithium borohydride, chlorotrimethylsilane / tetrahydrofuran / 20 h / Ambient temperature

2: 81 percent / triethylamine / CH₂Cl₂ / 0.33 h / 0 °C

With lithium borohydride; chloro-trimethyl-silane; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00086a017

Reference yield: 81.0%

ethyl (R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoate (139657-26-4) → (R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoic acid (139657-27-5)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water; for 0.666667h; Ambient temperature;

DOI:10.1021/jm00086a017

upstream raw materials:

ethyl 3-(chloroformyl)propionate

tricyclo<3.3.1.1^3,7>dec-2-yl <1-(1H-indol-3-ylmethyl)-1-methyl-2-<(2-phenylethyl)amino>ethyl>carbamate

tricyclo[3.3.1.1^3,7]dec-2-yl (R)-{1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl}carbamate

Downstream raw materials:

(R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoic acid

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