Technology Process of (1E,3R,4R,5E)-4-hydroxy-1-iodo-8-phenyl-3,5-dimethyl-1,5-octadiene
There total 6 articles about (1E,3R,4R,5E)-4-hydroxy-1-iodo-8-phenyl-3,5-dimethyl-1,5-octadiene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
DOI:10.1021/ja972603p
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium tert-butoxide; n-butyllithium; (-)-diisopinylcampheylmethoxyborane / tetrahydrofuran; hexane / -78 °C
1.2: boron trifluoride etherate / tetrahydrofuran; hexane; diethyl ether / 15 h / -78 °C
1.3: H2O2; aq. NaOH / tetrahydrofuran; hexane; diethyl ether / 3 h / 20 °C
2.1: imidazole / dimethylformamide / 20 °C
3.1: sodium periodate / tetrahydrofuran; H2O / 0.5 h
4.1: CrCl2 / tetrahydrofuran / 4 h / 0 °C
5.1: tetrabutylammonium fluoride / tetrahydrofuran / 6 h / 20 °C
With
1H-imidazole; chromium dichloride; sodium periodate; n-butyllithium; potassium tert-butylate; tetrabutyl ammonium fluoride; (-)-B-methoxydiisopinocampheylborane;
In
tetrahydrofuran; hexane; water; N,N-dimethyl-formamide;
1.1: Addition / 1.2: Addition / 1.3: Oxidation / 2.1: Etherification / 3.1: Oxidation / 4.1: Condensation / 5.1: Hydrolysis;
DOI:10.1021/jo000453m
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium periodate / tetrahydrofuran; H2O / 0.5 h
2: CrCl2 / tetrahydrofuran / 4 h / 0 °C
3: tetrabutylammonium fluoride / tetrahydrofuran / 6 h / 20 °C
With
chromium dichloride; sodium periodate; tetrabutyl ammonium fluoride;
In
tetrahydrofuran; water;
1: Oxidation / 2: Condensation / 3: Hydrolysis;
DOI:10.1021/jo000453m
