1-(1H-indol-3-yl)-2-phenylmethanesulfonyl-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 1-(1H-indol-3-yl)-2-phenylmethanesulfonyl-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 1123754-78-8
• Molecular Formula: C₂₄H₂₂N₂O₂S
• Molecular Weight: 402.517

Synonyms:1-(1H-indol-3-yl)-2-phenylmethanesulfonyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property of 1-(1H-indol-3-yl)-2-phenylmethanesulfonyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of 1-(1H-indol-3-yl)-2-phenylmethanesulfonyl-1,2,3,4-tetrahydroisoquinoline

There total 2 articles about 1-(1H-indol-3-yl)-2-phenylmethanesulfonyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-phenylmethyl-1-(1H-indol-3-yl)-1,2,3,4-tetrahydroisoquinoline (1260506-79-3) + benzenesulfonyl chloride (1939-99-7) → 1-(1H-indol-3-yl)-2-phenylmethanesulfonyl-1,2,3,4-tetrahydroisoquinoline (1123754-78-8)

Guidance literature:

2-phenylmethyl-1-(1H-indol-3-yl)-1,2,3,4-tetrahydroisoquinoline; With 10 wt% Pd(OH)2 on carbon; hydrogen; In ethanol; water; ethyl acetate;

benzenesulfonyl chloride; With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1039/c8ra02340a

Reference yield: 56.0%

3-((R)-2-phenylmethanesulfonyl-1,2,3,4-tetrahydroisoquinolin-1-yl)indole-1-carboxylic acid tert-butyl ester (1123754-75-5) → 1-(1H-indol-3-yl)-2-phenylmethanesulfonyl-1,2,3,4-tetrahydroisoquinoline (1123754-78-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jo802607f

upstream raw materials:

3-((R)-2-phenylmethanesulfonyl-1,2,3,4-tetrahydroisoquinolin-1-yl)indole-1-carboxylic acid tert-butyl ester

2-phenylmethyl-1-(1H-indol-3-yl)-1,2,3,4-tetrahydroisoquinoline

benzenesulfonyl chloride

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