3-[(2R)-(tert-butoxycarconylamino)-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-methyluracil

Base Information

Chemical Name:3-[(2R)-(tert-butoxycarconylamino)-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-methyluracil
CAS No.:848121-55-1
Molecular Formula:C₃₂H₃₃F₂N₃O₅
Molecular Weight:577.628
Hs Code.:

Synonyms:3-[(2R)-(tert-butoxycarconylamino)-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-methyluracil

Suppliers and Price of 3-[(2R)-(tert-butoxycarconylamino)-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-methyluracil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[(2R)-(tert-butoxycarconylamino)-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-methyluracil

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[(2R)-(tert-butoxycarconylamino)-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-methyluracil

There total 3 articles about 3-[(2R)-(tert-butoxycarconylamino)-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-methyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 10365-98-7,1107579-37-2
3-methoxyphenylboronic acid

: 352303-69-6
{(R)-2-[5-bromo-3-(2,6-difluoro-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

: 848121-55-1
3-[(2R)-(tert-butoxycarconylamino)-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-methyluracil

Guidance literature:: With barium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; benzene; at 80 ℃; for 18h;
DOI:10.1021/jm049218c

Reference yield:

: 67341-01-9,117049-14-6,138457-46-2,102089-74-7
(R)-N-(tert-butoxycarbonyl)phenylglycinol

: 848121-55-1
3-[(2R)-(tert-butoxycarconylamino)-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-methyluracil

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C

2: 93 percent / aq. Ba(OH)2; tetrakis(triphenylphosphine)palladium / benzene; ethanol; 1,2-dimethoxy-ethane / 18 h / 80 °C

With barium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; benzene; 1: Mitsunobu reaction / 2: Suzuki coupling;
DOI:10.1021/jm049218c

Reference yield:

: 352303-66-3
5-bromo-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione

: 848121-55-1
3-[(2R)-(tert-butoxycarconylamino)-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-methyluracil

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C

2: 93 percent / aq. Ba(OH)2; tetrakis(triphenylphosphine)palladium / benzene; ethanol; 1,2-dimethoxy-ethane / 18 h / 80 °C

With barium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; benzene; 1: Mitsunobu reaction / 2: Suzuki coupling;
DOI:10.1021/jm049218c