4-{(2S,3S,4R,5S)-5-[(2S,3S)-3-((1R,2S)-1-Methyl-2-trimethylsilanyloxy-propyl)-oxiranylmethyl]-3,4-bis-trimethylsilanyloxy-tetrahydro-pyran-2-ylmethyl}-2-phenyl-thiazole

Base Information

Chemical Name:4-{(2S,3S,4R,5S)-5-[(2S,3S)-3-((1R,2S)-1-Methyl-2-trimethylsilanyloxy-propyl)-oxiranylmethyl]-3,4-bis-trimethylsilanyloxy-tetrahydro-pyran-2-ylmethyl}-2-phenyl-thiazole
CAS No.:169603-72-9
Molecular Formula:C₃₁H₅₃NO₅SSi₃
Molecular Weight:636.088
Hs Code.:

4-{(2S,3S,4R,5S)-5-[(2S,3S)-3-((1R,2S)-1-Methyl-2-trimethylsilanyloxy-propyl)-oxiranylmethyl]-3,4-bis-trimethylsilanyloxy-tetrahydro-pyran-2-ylmethyl}-2-phenyl-thiazole

Synonyms:4-{(2S,3S,4R,5S)-5-[(2S,3S)-3-((1R,2S)-1-Methyl-2-trimethylsilanyloxy-propyl)-oxiranylmethyl]-3,4-bis-trimethylsilanyloxy-tetrahydro-pyran-2-ylmethyl}-2-phenyl-thiazole

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Chemical Property of 4-{(2S,3S,4R,5S)-5-[(2S,3S)-3-((1R,2S)-1-Methyl-2-trimethylsilanyloxy-propyl)-oxiranylmethyl]-3,4-bis-trimethylsilanyloxy-tetrahydro-pyran-2-ylmethyl}-2-phenyl-thiazole

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Technology Process of 4-{(2S,3S,4R,5S)-5-[(2S,3S)-3-((1R,2S)-1-Methyl-2-trimethylsilanyloxy-propyl)-oxiranylmethyl]-3,4-bis-trimethylsilanyloxy-tetrahydro-pyran-2-ylmethyl}-2-phenyl-thiazole

There total 3 articles about 4-{(2S,3S,4R,5S)-5-[(2S,3S)-3-((1R,2S)-1-Methyl-2-trimethylsilanyloxy-propyl)-oxiranylmethyl]-3,4-bis-trimethylsilanyloxy-tetrahydro-pyran-2-ylmethyl}-2-phenyl-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 191923-28-1
4-{(2S,3S,4R,5S)-5-[(2S,3S)-3-((1R,2S)-1-Methyl-2-trimethylsilanyloxy-propyl)-oxiranylmethyl]-3,4-bis-trimethylsilanyloxy-tetrahydro-pyran-2-ylmethyl}-2-phenyl-4,5-dihydro-thiazol-4-ol

: 169603-72-9
4-{(2S,3S,4R,5S)-5-[(2S,3S)-3-((1R,2S)-1-Methyl-2-trimethylsilanyloxy-propyl)-oxiranylmethyl]-3,4-bis-trimethylsilanyloxy-tetrahydro-pyran-2-ylmethyl}-2-phenyl-thiazole

Guidance literature:: With dmap; methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 ℃; for 1h; Yield given;
DOI:10.1021/jm960738k

Reference yield:

: 87407-95-2
<(2S,3R,4R,5S)-3,4-bis<(trimethylsilyl)oxy>-5-<(2S,3S,4S,5S)-2,3-epoxy-5-<(trimethylsilyl)oxy>-4-methylhexyl>tetrahydropyran-2-yl>acetone

: 169603-72-9
4-{(2S,3S,4R,5S)-5-[(2S,3S)-3-((1R,2S)-1-Methyl-2-trimethylsilanyloxy-propyl)-oxiranylmethyl]-3,4-bis-trimethylsilanyloxy-tetrahydro-pyran-2-ylmethyl}-2-phenyl-thiazole

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) triethylamine, (trimethylsilyl)trifluoromethanesulfonate, 2.) N-bromosuccinimide / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, RT, 30 min

2: triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

3: triethylamine, methanesulfonyl chloride, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h / 0 °C

With dmap; N-Bromosuccinimide; trimethylsilyl trifluoromethanesulfonate; methanesulfonyl chloride; triethylamine; In dichloromethane;
DOI:10.1021/jm960738k

Reference yield:

: 1054660-21-7
1-Bromo-3-{(2S,3S,4R,5S)-5-[(2S,3S)-3-((1R,2S)-1-methyl-2-trimethylsilanyloxy-propyl)-oxiranylmethyl]-3,4-bis-trimethylsilanyloxy-tetrahydro-pyran-2-yl}-propan-2-one

: 169603-72-9
4-{(2S,3S,4R,5S)-5-[(2S,3S)-3-((1R,2S)-1-Methyl-2-trimethylsilanyloxy-propyl)-oxiranylmethyl]-3,4-bis-trimethylsilanyloxy-tetrahydro-pyran-2-ylmethyl}-2-phenyl-thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

2: triethylamine, methanesulfonyl chloride, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h / 0 °C

With dmap; methanesulfonyl chloride; triethylamine; In dichloromethane;
DOI:10.1021/jm960738k