5-Amino-1-methyl-2-oxoindoline

Base Information

• Chemical Name: 5-Amino-1-methyl-2-oxoindoline
• CAS No.: 20870-91-1
• Molecular Formula: C9H10N2O
• Molecular Weight: 162.191
• Hs Code.: 2933790090
• Mol file: 20870-91-1.mol

Synonyms:2-Indolinone,5-amino-1-methyl- (8CI);5-Amino-1-methyl-1,3-dihydroindol-2-one;5-Amino-1-methylindolin-2-one;

Chemical Property of 5-Amino-1-methyl-2-oxoindoline

Chemical Property:

• Vapor Pressure: 4.47E-09mmHg at 25°C
• Melting Point: 109 °C
• Refractive Index: 1.643
• Boiling Point: 471.9 °C at 760 mmHg
• PKA: 3.51±0.20(Predicted)
• Flash Point: 239.2 °C
• PSA: 46.33000
• Density: 1.263 g/cm³
• LogP: 1.43390
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

5-Amino-1-methyl-2-oxoindoline ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-36/37/38
• Safety Statements: 22-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Amino-1-methyl-2-oxoindoline

There total 5 articles about 5-Amino-1-methyl-2-oxoindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-methyl-5-nitro-1,3-dihydro-indol-2-one (20870-89-7) → 5-amino-1-methyl-1,3-dihydro-2H-indol-2-one (20870-91-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 18h;

Reference yield:

2-chloro-N-methyl-N-(4-nitrophenyl)acetamide (2653-16-9) → 5-amino-1-methyl-1,3-dihydro-2H-indol-2-one (20870-91-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos / toluene / 3 h / 80 °C

2: hydrogen / palladium on activated charcoal / methanol / 18 h

With hydrogen; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; johnphos; In methanol; toluene;

Reference yield:

N-methyl(p-nitroaniline) (100-15-2) → 5-amino-1-methyl-1,3-dihydro-2H-indol-2-one (20870-91-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / water; ethyl acetate / 1.08 h / 0 - 20 °C

2: triethylamine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos / toluene / 3 h / 80 °C

3: hydrogen / palladium on activated charcoal / methanol / 18 h

With potassium hydroxide; hydrogen; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; johnphos; In methanol; water; ethyl acetate; toluene;

upstream raw materials:

1-methyl-5-nitro-1,3-dihydro-indol-2-one

N-methyl-2-indolinone

2-chloro-N-methyl-N-(4-nitrophenyl)acetamide

N-methyl(p-nitroaniline)

Refernces

• 1、 -. "INHIBITORS OF FOCAL ADHESION KINASE". Page/Page column 147. . Retrieved 2008/12/07.
• 2、 -. "Oxindole oxazolidinone as antibacterial agent". Page/Page column 10. . Retrieved 2008/06/13.