2'-O-{[(S)-1-(2-nitrophenyl)ethoxy]methyl}adenosine (5'-methyl phosphate)-3'-{N-{[(RS)-1-(2-nitrophenyl)ethoxy]carbonyl}-L-phenylalaninate}

Base Information

Chemical Name:2'-O-{[(S)-1-(2-nitrophenyl)ethoxy]methyl}adenosine (5'-methyl phosphate)-3'-{N-{[(RS)-1-(2-nitrophenyl)ethoxy]carbonyl}-L-phenylalaninate}
CAS No.:312710-08-0
Molecular Formula:C₃₈H₄₁N₈O₁₅P
Molecular Weight:880.762
Hs Code.:

Synonyms:2'-O-{[(S)-1-(2-nitrophenyl)ethoxy]methyl}adenosine (5'-methyl phosphate)-3'-{N-{[(RS)-1-(2-nitrophenyl)ethoxy]carbonyl}-L-phenylalaninate}

Suppliers and Price of 2'-O-{[(S)-1-(2-nitrophenyl)ethoxy]methyl}adenosine (5'-methyl phosphate)-3'-{N-{[(RS)-1-(2-nitrophenyl)ethoxy]carbonyl}-L-phenylalaninate}

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2'-O-{[(S)-1-(2-nitrophenyl)ethoxy]methyl}adenosine (5'-methyl phosphate)-3'-{N-{[(RS)-1-(2-nitrophenyl)ethoxy]carbonyl}-L-phenylalaninate}

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2'-O-{[(S)-1-(2-nitrophenyl)ethoxy]methyl}adenosine (5'-methyl phosphate)-3'-{N-{[(RS)-1-(2-nitrophenyl)ethoxy]carbonyl}-L-phenylalaninate}

There total 4 articles about 2'-O-{[(S)-1-(2-nitrophenyl)ethoxy]methyl}adenosine (5'-methyl phosphate)-3'-{N-{[(RS)-1-(2-nitrophenyl)ethoxy]carbonyl}-L-phenylalaninate} which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 312710-10-4
N-{[(RS)-1-(2-nitrophenyl)ethoxy]carbonyl}-L-phenylalanine

: 2'-O-{[(1S)-1-(2-nitrophenyl)ethoxy]methyl}adenosine 5'-(triethylammonium methyl phosphate)

: 312710-08-0
2'-O-{[(S)-1-(2-nitrophenyl)ethoxy]methyl}adenosine (5'-methyl phosphate)-3'-{N-{[(RS)-1-(2-nitrophenyl)ethoxy]carbonyl}-L-phenylalaninate}

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 4-pyrrolidin-1-ylpyridine; N-ethyl-N,N-diisopropylamine; In pyridine; at 20 ℃;
DOI:10.1002/1522-2675(20000906)83:9<2477::AID-HLCA2477>3.0.CO;2-9

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 312710-08-0
2'-O-{[(S)-1-(2-nitrophenyl)ethoxy]methyl}adenosine (5'-methyl phosphate)-3'-{N-{[(RS)-1-(2-nitrophenyl)ethoxy]carbonyl}-L-phenylalaninate}

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / 1H-tetrazole / dimethylformamide / 14 h / 80 °C

2: 45 percent / BOP; iPr₂NEt; 4-(pyrrolidin-1-yl)pyridine / pyridine / 20 °C

With 1H-tetrazole; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 4-pyrrolidin-1-ylpyridine; N-ethyl-N,N-diisopropylamine; In pyridine; N,N-dimethyl-formamide; 1: Substitution / 2: Condensation;
DOI:10.1002/1522-2675(20000906)83:9<2477::AID-HLCA2477>3.0.CO;2-9

Reference yield:

: 80379-10-8,108530-03-6,142631-59-2,3205-25-2
1-(2-nitrophenyl)ethan-1-ol

: 312710-08-0
2'-O-{[(S)-1-(2-nitrophenyl)ethoxy]methyl}adenosine (5'-methyl phosphate)-3'-{N-{[(RS)-1-(2-nitrophenyl)ethoxy]carbonyl}-L-phenylalaninate}

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / CH₂Cl₂ / 0.5 h / 20 °C

2: 53 percent / 1H-tetrazole / dimethylformamide / 14 h / 80 °C

3: 45 percent / BOP; iPr₂NEt; 4-(pyrrolidin-1-yl)pyridine / pyridine / 20 °C

With 1H-tetrazole; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 4-pyrrolidin-1-ylpyridine; N-ethyl-N,N-diisopropylamine; In pyridine; dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: Substitution / 3: Condensation;
DOI:10.1002/1522-2675(20000906)83:9<2477::AID-HLCA2477>3.0.CO;2-9