6-chloro-4-ethoxy-3-(4-(4-fluoro-3-(trifluoromethoxy)phenoxy)phenyl)-7-methoxy-2-methylquinoline

Base Information

Chemical Name:6-chloro-4-ethoxy-3-(4-(4-fluoro-3-(trifluoromethoxy)phenoxy)phenyl)-7-methoxy-2-methylquinoline
CAS No.:1599467-75-0
Molecular Formula:C₂₆H₂₀ClF₄NO₄
Molecular Weight:521.896
Hs Code.:

Synonyms:6-chloro-4-ethoxy-3-(4-(4-fluoro-3-(trifluoromethoxy)phenoxy)phenyl)-7-methoxy-2-methylquinoline

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Chemical Property of 6-chloro-4-ethoxy-3-(4-(4-fluoro-3-(trifluoromethoxy)phenoxy)phenyl)-7-methoxy-2-methylquinoline

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Technology Process of 6-chloro-4-ethoxy-3-(4-(4-fluoro-3-(trifluoromethoxy)phenoxy)phenyl)-7-methoxy-2-methylquinoline

There total 8 articles about 6-chloro-4-ethoxy-3-(4-(4-fluoro-3-(trifluoromethoxy)phenoxy)phenyl)-7-methoxy-2-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1354745-86-0
6-chloro-4-ethoxy-3-iodo-7-methoxy-2-methylquinoline

: 1599467-69-2
2-(4-(4-fluoro-3-(trifluoromethoxy)phenoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1599467-75-0
6-chloro-4-ethoxy-3-(4-(4-fluoro-3-(trifluoromethoxy)phenoxy)phenyl)-7-methoxy-2-methylquinoline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; N,N-dimethyl-formamide; at 85 ℃; for 18h;
DOI:10.1021/jm500147k

Reference yield:

: C₁₃H₁₆ClNO₃

: 1599467-75-0
6-chloro-4-ethoxy-3-(4-(4-fluoro-3-(trifluoromethoxy)phenoxy)phenyl)-7-methoxy-2-methylquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: dowtherm A / 0.33 h / 250 °C

2.1: iodine; potassium iodide; N-butylamine / water; N,N-dimethyl-formamide / 12 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C

3.2: 8 h / 50 °C

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 18 h / 85 °C

With dowtherm A; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; potassium carbonate; N-butylamine; potassium iodide; In water; N,N-dimethyl-formamide; 4.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm500147k

Reference yield:

: 106-41-2
4-bromo-phenol

: 1599467-75-0
6-chloro-4-ethoxy-3-(4-(4-fluoro-3-(trifluoromethoxy)phenoxy)phenyl)-7-methoxy-2-methylquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: copper diacetate; N-ethyl-N,N-diisopropylamine; pyridine / dichloromethane / 12 h / 20 °C / Molecular sieve

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / N,N-dimethyl-formamide / 18 h / 80 °C / Molecular sieve

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 18 h / 85 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; copper diacetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide; 3: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm500147k