cis-3-acetoxy-4-<((2-(3-indolyl)ethyl)amino)methyl>-1-(phenylthio)cyclohexene

Base Information

Chemical Name:cis-3-acetoxy-4-<((2-(3-indolyl)ethyl)amino)methyl>-1-(phenylthio)cyclohexene
CAS No.:99766-08-2
Molecular Formula:C₂₅H₂₈N₂O₂S
Molecular Weight:420.576
Hs Code.:

Synonyms:cis-3-acetoxy-4-<((2-(3-indolyl)ethyl)amino)methyl>-1-(phenylthio)cyclohexene

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Chemical Property of cis-3-acetoxy-4-<((2-(3-indolyl)ethyl)amino)methyl>-1-(phenylthio)cyclohexene

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Technology Process of cis-3-acetoxy-4-<((2-(3-indolyl)ethyl)amino)methyl>-1-(phenylthio)cyclohexene

There total 1 articles about cis-3-acetoxy-4-<((2-(3-indolyl)ethyl)amino)methyl>-1-(phenylthio)cyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61-54-1
tryptamine

: 90083-86-6,99766-07-1
cis-3-Acetoxy-4-formyl-1-(phenylthio)cyclohexene

: 99766-08-2
cis-3-acetoxy-4-<((2-(3-indolyl)ethyl)amino)methyl>-1-(phenylthio)cyclohexene

Guidance literature:: With sodium tetrahydroborate; magnesium sulfate; Yield given. Multistep reaction; 1.) methylene dichloride, -23 dec C, 11 h, 2.) methylene dichloride, methanol, -63 deg C, 0.75 h;
DOI:10.1021/jo00354a015

Reference yield: 94.0%

: 99766-14-0
(p-tolylsulfonyl)acetyl chloride

: 99766-08-2
cis-3-acetoxy-4-<((2-(3-indolyl)ethyl)amino)methyl>-1-(phenylthio)cyclohexene

: 99766-09-3
cis-3-acetoxy-4<((2-(3-indolyl)ethyl)((p-tolylsulfonyl)-acetyl)amino)methyl>-1-(phenylthio)cyclohexene

Guidance literature:: With triethylamine; In dichloromethane; at -23 ℃; for 0.25h; Title compound not separated from byproducts;
DOI:10.1021/jo00354a015

Reference yield:

: 99766-08-2
cis-3-acetoxy-4-<((2-(3-indolyl)ethyl)amino)methyl>-1-(phenylthio)cyclohexene

: 99766-15-1
3-<2-(3-indolyl)ethyl>-4-oxo-8-(phenylthio)-cis-3-azabicyclo<4.4.0>dec-7-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / Et₃N / CH₂Cl₂ / 0.25 h / -23 °C

2: 94 percent / NaH, Pd(diphos)2 / 1,2-dimethoxy-ethane / 1.) 0 deg C, 40 min, 2.) 85 deg C, 10 min

3: 90.9 percent / Na₂HPO₄, (Na)Hg / methanol / 1 h / Ambient temperature

With disodium hydrogenphosphate; sodium amalgam; bis[1,2-bis(diphenylphosphino)ethane]palladium⁽⁰⁾; sodium hydride; triethylamine; In methanol; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jo00354a015