2-(Aminomethyl)-5-methylthiophene hydrochloride

Base Information

• Chemical Name: 2-(Aminomethyl)-5-methylthiophene hydrochloride
• CAS No.: 171661-55-5
• Molecular Formula: C₆H₉NS*ClH
• Molecular Weight: 163.671
• Hs Code.: 2934999090
• Mol file: 171661-55-5.mol

Synonyms:2-Thiophenemethanamine,5-methyl-, hydrochloride (9CI);

Chemical Property of 2-(Aminomethyl)-5-methylthiophene hydrochloride

Chemical Property:

• Vapor Pressure: 0.0325mmHg at 25°C
• Melting Point: 191-193°C
• Boiling Point: 239.3 °C at 760 mmHg
• Flash Point: 98.5 °C
• PSA: 54.26000
• LogP: 3.01750
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

(5-Methylthien-2-yl)methylamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Harmful:
• Statements: 22-36/37/38
• Safety Statements: 22-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Aminomethyl)-5-methylthiophene hydrochloride

There total 3 articles about 2-(Aminomethyl)-5-methylthiophene hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(5-methylthiophen-2-ylmethyl)amine (104163-34-0) → (5-methylthien-2-yl)methylamine hydrochloride (171661-55-5)

Guidance literature:

With hydrogenchloride; In diethyl ether;

Reference yield:

5-methylthiophene-2-carboxaldehyde (13679-70-4) → (5-methylthien-2-yl)methylamine hydrochloride (171661-55-5)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 1 h / Heating / reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / Heating / reflux

3: hydrogenchloride / diethyl ether

With hydrogenchloride; lithium aluminium tetrahydride; hydroxylamine hydrochloride; sodium acetate; In tetrahydrofuran; diethyl ether; ethanol; water;

Reference yield:

(E)-5-methylthiophen-2-carbaldehyde oxime → (5-methylthien-2-yl)methylamine hydrochloride (171661-55-5)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / Heating / reflux

2: hydrogenchloride / diethyl ether

With hydrogenchloride; lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether;

upstream raw materials:

(5-methylthiophen-2-ylmethyl)amine

5-methylthiophene-2-carboxaldehyde

Refernces