ethyl <2,3-dichloro-4-<3-<(tert-butoxycarboxamido)methyl>-4-hydroxybenzoyl>phenoxy>acetate

Base Information

• Chemical Name: ethyl <2,3-dichloro-4-<3-<(tert-butoxycarboxamido)methyl>-4-hydroxybenzoyl>phenoxy>acetate
• CAS No.: 92285-19-3
• Molecular Formula: C₂₃H₂₅Cl₂NO₇
• Molecular Weight: 498.36
• Mol file: 92285-19-3.mol

Synonyms:ethyl <2,3-dichloro-4-<3-<(tert-butoxycarboxamido)methyl>-4-hydroxybenzoyl>phenoxy>acetate

Chemical Property of ethyl <2,3-dichloro-4-<3-<(tert-butoxycarboxamido)methyl>-4-hydroxybenzoyl>phenoxy>acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl <2,3-dichloro-4-<3-<(tert-butoxycarboxamido)methyl>-4-hydroxybenzoyl>phenoxy>acetate

There total 1 articles about ethyl <2,3-dichloro-4-<3-<(tert-butoxycarboxamido)methyl>-4-hydroxybenzoyl>phenoxy>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

di-tert-butyl dicarbonate (24424-99-5) + ethyl {2,3-dichloro-4-[3-(aminomethyl)-4-hydroxybenzoyl]phenoxy}acetate hydrochloride (78235-46-8) → ethyl <2,3-dichloro-4-<3-<(tert-butoxycarboxamido)methyl>-4-hydroxybenzoyl>phenoxy>acetate (92285-19-3)

Guidance literature:

With potassium hydrogencarbonate; In water; acetonitrile; for 1.5h;

DOI:10.1021/jm00378a011

Reference yield: 82.0%

ethyl <2,3-dichloro-4-<3-<(tert-butoxycarboxamido)methyl>-4-hydroxybenzoyl>phenoxy>acetate (92285-19-3) → <2,3-dichloro-4-<3-<(tert-butoxycarboxamido)methyl>-4-hydroxybenzoyl>phenoxy>acetamide (92285-20-6)

Guidance literature:

With ammonia; In ethanol; for 30h; Ambient temperature;

DOI:10.1021/jm00378a011

Reference yield:

ethyl <2,3-dichloro-4-<3-<(tert-butoxycarboxamido)methyl>-4-hydroxybenzoyl>phenoxy>acetate (92285-19-3) → <2,3-dichloro-4-<3-(tert-butoxycarboxamido)methyl-4-hydroxybenzoyl>phenoxy>acetonitrile (92285-21-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / NH₃ (g) / ethanol / 30 h / Ambient temperature

2: 70 percent / pyridine, trifluoroacetic anhydride / CH₂Cl₂ / 2.5 h / Ambient temperature

With pyridine; ammonia; trifluoroacetic anhydride; In ethanol; dichloromethane;

DOI:10.1021/jm00378a011

upstream raw materials:

di-tert-butyl dicarbonate

ethyl {2,3-dichloro-4-[3-(aminomethyl)-4-hydroxybenzoyl]phenoxy}acetate hydrochloride

Downstream raw materials:

<2,3-dichloro-4-<3-<(tert-butoxycarboxamido)methyl>-4-hydroxybenzoyl>phenoxy>acetamide

<2,3-dichloro-4-<3-(aminomethyl)-4-hydroxybenzoyl>phenoxy>acetonitrile

<2,3-dichloro-4-<3-(tert-butoxycarboxamido)methyl-4-hydroxybenzoyl>phenoxy>acetonitrile