N-<(1R-(1α,2α,3α))-2-(hydroxymethyl)-3-(2-propyl)-cyclopropanoyl>-N'-(p-methoxybenzyl)-O-methyl-L-tyrosine-N-methylamide

Base Information

Chemical Name:N-<(1R-(1α,2α,3α))-2-(hydroxymethyl)-3-(2-propyl)-cyclopropanoyl>-N'-(p-methoxybenzyl)-O-methyl-L-tyrosine-N-methylamide
CAS No.:149859-35-8
Molecular Formula:C₂₇H₃₆N₂O₅
Molecular Weight:468.593
Hs Code.:

Synonyms:N-<(1R-(1α,2α,3α))-2-(hydroxymethyl)-3-(2-propyl)-cyclopropanoyl>-N'-(p-methoxybenzyl)-O-methyl-L-tyrosine-N-methylamide

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Chemical Property of N-<(1R-(1α,2α,3α))-2-(hydroxymethyl)-3-(2-propyl)-cyclopropanoyl>-N'-(p-methoxybenzyl)-O-methyl-L-tyrosine-N-methylamide

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Technology Process of N-<(1R-(1α,2α,3α))-2-(hydroxymethyl)-3-(2-propyl)-cyclopropanoyl>-N'-(p-methoxybenzyl)-O-methyl-L-tyrosine-N-methylamide

There total 7 articles about N-<(1R-(1α,2α,3α))-2-(hydroxymethyl)-3-(2-propyl)-cyclopropanoyl>-N'-(p-methoxybenzyl)-O-methyl-L-tyrosine-N-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82290-65-1
(Z)-4-methylpent-2-en-1-ol

: 149859-35-8
N-<(1R-(1α,2α,3α))-2-(hydroxymethyl)-3-(2-propyl)-cyclopropanoyl>-N'-(p-methoxybenzyl)-O-methyl-L-tyrosine-N-methylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / N,N-dimethylaniline, Et₃N / CH₂Cl₂ / 1) 0 deg C, 15 min, 2) r.t., 30 min

2: 85 percent / Rh₂<-CH₂-CH₂-CH(CO₂Me)-N=CO->4 / CH₂Cl₂ / Heating

3: 1) Me₃Al / 1) hexane, ClCH₂CH₂Cl, r.t., 1 h, 2) ClCH₂CH₂Cl, 83 deg C, 36 h

With trimethylaluminum; N,N-dimethyl-aniline; triethylamine; Rh2<-CH2-CH2-CH(CO2Me)-N=CO->4; In dichloromethane;
DOI:10.1016/S0040-4020(01)90212-1

Reference yield:

: 149859-29-0
4-methyl-2(Z)-pentenyl diazoacetate

: 149859-35-8
N-<(1R-(1α,2α,3α))-2-(hydroxymethyl)-3-(2-propyl)-cyclopropanoyl>-N'-(p-methoxybenzyl)-O-methyl-L-tyrosine-N-methylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / Rh₂<-CH₂-CH₂-CH(CO₂Me)-N=CO->4 / CH₂Cl₂ / Heating

2: 1) Me₃Al / 1) hexane, ClCH₂CH₂Cl, r.t., 1 h, 2) ClCH₂CH₂Cl, 83 deg C, 36 h

With trimethylaluminum; Rh2<-CH2-CH2-CH(CO2Me)-N=CO->4; In dichloromethane;
DOI:10.1016/S0040-4020(01)90212-1

Reference yield:

: 3978-80-1
Boc-Tyr-OH

: 149859-35-8
N-<(1R-(1α,2α,3α))-2-(hydroxymethyl)-3-(2-propyl)-cyclopropanoyl>-N'-(p-methoxybenzyl)-O-methyl-L-tyrosine-N-methylamide

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NaOH

2: 1) i-BuOCOCl, NMM / 1) CH₂Cl₂, -60 deg C

3: HCl / dioxane; acetic acid

4: 81 percent / NaBH₄, 3 Angstroem molecular sieve / methanol

5: 1) Me₃Al / 1) hexane, ClCH₂CH₂Cl, r.t., 1 h, 2) ClCH₂CH₂Cl, 83 deg C, 36 h

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; 3 A molecular sieve; trimethylaluminum; isobutyl chloroformate; In 1,4-dioxane; methanol; acetic acid;
DOI:10.1016/S0040-4020(01)90212-1