N-(3-(5-fluoro-2-(3-(3-(2-oxopyrrolidin-1-yl)propoxy)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

Base Information

Chemical Name:N-(3-(5-fluoro-2-(3-(3-(2-oxopyrrolidin-1-yl)propoxy)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide
CAS No.:1202757-69-4
Molecular Formula:C₂₆H₂₆FN₅O₄
Molecular Weight:491.522
Hs Code.:

Synonyms:N-(3-(5-fluoro-2-(3-(3-(2-oxopyrrolidin-1-yl)propoxy)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

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Chemical Property of N-(3-(5-fluoro-2-(3-(3-(2-oxopyrrolidin-1-yl)propoxy)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

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Technology Process of N-(3-(5-fluoro-2-(3-(3-(2-oxopyrrolidin-1-yl)propoxy)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

There total 7 articles about N-(3-(5-fluoro-2-(3-(3-(2-oxopyrrolidin-1-yl)propoxy)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1202760-37-9
C₂₃H₂₄FN₅O₃

: 814-68-6,25189-84-8
acryloyl chloride

: 1202757-69-4
N-(3-(5-fluoro-2-(3-(3-(2-oxopyrrolidin-1-yl)propoxy)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

Guidance literature:: With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 0 ℃; for 0.75h;

Reference yield:

: 402-67-5
3-fluoro-1-nitrobenzene

: 1202757-69-4
N-(3-(5-fluoro-2-(3-(3-(2-oxopyrrolidin-1-yl)propoxy)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

1.2: 16 h / 20 °C

2.1: hydrogenchloride; tin(ll) chloride / water / 2 h / 50 °C

3.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 100 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

5.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 0.75 h / 0 °C

With hydrogenchloride; sodium hydride; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; tin(ll) chloride; palladium diacetate; In 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 62012-15-1
1-(3-hydroxypropyl)pyrrolidin-2-one

: 1202757-69-4
N-(3-(5-fluoro-2-(3-(3-(2-oxopyrrolidin-1-yl)propoxy)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

1.2: 16 h / 20 °C

2.1: hydrogenchloride; tin(ll) chloride / water / 2 h / 50 °C

3.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 100 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

5.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 0.75 h / 0 °C

With hydrogenchloride; sodium hydride; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; tin(ll) chloride; palladium diacetate; In 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide; toluene;