Technology Process of 2,2-Dimethyl-thiopropionic acid S-(2-{1-[(Z)-4-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-7-trimethylsilanyl-hept-4-ene-1,6-diynyl]-cyclopropyl}-ethyl) ester
There total 11 articles about 2,2-Dimethyl-thiopropionic acid S-(2-{1-[(Z)-4-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-7-trimethylsilanyl-hept-4-ene-1,6-diynyl]-cyclopropyl}-ethyl) ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 95 percent / 4-(dimethylamino)pyridine, triethylamine / tetrahydrofuran / 3.5 h / 23 °C
2: 1.) tert-butyllithium / 1.) THF, Et2O, pentane, -120 deg C, 2.) THF, Et2O, pentane, from -120 to -40 deg C, 3 h
3: 1.) lithium diisopropylamide, Cerium(III) chloride / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 40 min
With
dmap; cerium(III) chloride; tert.-butyl lithium; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 94 percent / diisobutylaluminum hydride / hexane; toluene / a) -78 deg C, 30 min, b) 0 deg C, 30 min
2: 95 percent / 4-(dimethylamino)pyridine, triethylamine / tetrahydrofuran / 3.5 h / 23 °C
3: 1.) tert-butyllithium / 1.) THF, Et2O, pentane, -120 deg C, 2.) THF, Et2O, pentane, from -120 to -40 deg C, 3 h
4: 1.) lithium diisopropylamide, Cerium(III) chloride / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 40 min
With
dmap; cerium(III) chloride; tert.-butyl lithium; diisobutylaluminium hydride; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine / CH2Cl2 / 0.08 h / 0 °C
2: 90 percent / triethylamine / tetrahydrofuran / 3 h / 50 °C
3: 1.) lithium diisopropylamide, Cerium(III) chloride / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 40 min
With
cerium(III) chloride; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane;
