Technology Process of [5-(3,5-bis-trifluoromethyl-benzenesulfonylamino)-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy]-acetic acid
There total 6 articles about [5-(3,5-bis-trifluoromethyl-benzenesulfonylamino)-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy]-acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
[5-(3,5-bis-trifluoromethyl-benzenesulfonylamino)-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy]-acetic acid tert-butyl ester;
With
lithium hydroxide monohydrate; water;
In
tetrahydrofuran;
at 20 ℃;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos / 1,4-dioxane; water / 80 °C / Inert atmosphere
2.1: caesium carbonate / acetonitrile / 20 °C / Inert atmosphere
3.1: ammonium acetate / methanol / 20 °C / Inert atmosphere
3.2: 0 - 20 °C
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere
4.2: 20 °C
5.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C
With
lithium hydroxide monohydrate; ammonium acetate; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: bromine; aluminum (III) chloride / 80 °C / Inert atmosphere
2.1: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos / 1,4-dioxane; water / 80 °C / Inert atmosphere
3.1: caesium carbonate / acetonitrile / 20 °C / Inert atmosphere
4.1: ammonium acetate / methanol / 20 °C / Inert atmosphere
4.2: 0 - 20 °C
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere
5.2: 20 °C
6.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C
With
aluminum (III) chloride; lithium hydroxide monohydrate; ammonium acetate; water; bromine; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;
![[5-(3,5-bis-trifluoromethyl-benzenesulfonylamino)-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy]-acetic acid tert-butyl ester](/Databaselist/images/loading.webp)
