N-(2-Benzo[1,3]dioxol-5-yl-ethyl)-2-(4-methoxy-benzo[1,3]dioxol-5-yl)-N-((R)-1-phenyl-ethyl)-acetamide

Base Information

• Chemical Name: N-(2-Benzo[1,3]dioxol-5-yl-ethyl)-2-(4-methoxy-benzo[1,3]dioxol-5-yl)-N-((R)-1-phenyl-ethyl)-acetamide
• CAS No.: 181780-95-0
• Molecular Formula: C₂₇H₂₇NO₆
• Molecular Weight: 461.514
• Mol file: 181780-95-0.mol

Synonyms:N-(2-Benzo[1,3]dioxol-5-yl-ethyl)-2-(4-methoxy-benzo[1,3]dioxol-5-yl)-N-((R)-1-phenyl-ethyl)-acetamide

Chemical Property of N-(2-Benzo[1,3]dioxol-5-yl-ethyl)-2-(4-methoxy-benzo[1,3]dioxol-5-yl)-N-((R)-1-phenyl-ethyl)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-Benzo[1,3]dioxol-5-yl-ethyl)-2-(4-methoxy-benzo[1,3]dioxol-5-yl)-N-((R)-1-phenyl-ethyl)-acetamide

There total 8 articles about N-(2-Benzo[1,3]dioxol-5-yl-ethyl)-2-(4-methoxy-benzo[1,3]dioxol-5-yl)-N-((R)-1-phenyl-ethyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.3%

(4-Methoxy-benzo[1,3]dioxol-5-yl)-acetyl chloride (181780-92-7) + (2-Benzo[1,3]dioxol-5-yl-ethyl)-((R)-1-phenyl-ethyl)-amine (181780-94-9) → N-(2-Benzo[1,3]dioxol-5-yl-ethyl)-2-(4-methoxy-benzo[1,3]dioxol-5-yl)-N-((R)-1-phenyl-ethyl)-acetamide (181780-95-0)

Guidance literature:

With sodium carbonate; In diethyl ether; at 0 - 5 ℃; for 2h;

Reference yield:

2-methoxy-3,4-methylenedioxybenzyl alcohol (108261-13-8) → N-(2-Benzo[1,3]dioxol-5-yl-ethyl)-2-(4-methoxy-benzo[1,3]dioxol-5-yl)-N-((R)-1-phenyl-ethyl)-acetamide (181780-95-0)

Guidance literature:

Multi-step reaction with 5 steps

1: SOCl₂, PhNMe₂ / benzene / 4 h / 100 °C

2: dimethylsulfoxide / 2 h / 40 - 50 °C

3: 85.7 percent / KOH / ethanol; bis-(2-hydroxy-ethyl) ether / 21 h / Heating

4: SOCl₂

5: 61.3 percent / 5percent aq. Na₂CO₃ / diethyl ether / 2 h / 0 - 5 °C

With potassium hydroxide; thionyl chloride; sodium carbonate; N,N-dimethyl-aniline; In diethyl ether; ethanol; dimethyl sulfoxide; diethylene glycol; benzene;

Reference yield:

2-Methoxy-3,4-methylendioxy-benzylchlorid (2220-17-9) → N-(2-Benzo[1,3]dioxol-5-yl-ethyl)-2-(4-methoxy-benzo[1,3]dioxol-5-yl)-N-((R)-1-phenyl-ethyl)-acetamide (181780-95-0)

Guidance literature:

Multi-step reaction with 4 steps

1: dimethylsulfoxide / 2 h / 40 - 50 °C

2: 85.7 percent / KOH / ethanol; bis-(2-hydroxy-ethyl) ether / 21 h / Heating

3: SOCl₂

4: 61.3 percent / 5percent aq. Na₂CO₃ / diethyl ether / 2 h / 0 - 5 °C

With potassium hydroxide; thionyl chloride; sodium carbonate; In diethyl ether; ethanol; dimethyl sulfoxide; diethylene glycol;

upstream raw materials:

(4-Methoxy-benzo[1,3]dioxol-5-yl)-acetyl chloride

(2-Benzo[1,3]dioxol-5-yl-ethyl)-((R)-1-phenyl-ethyl)-amine

2-Methoxy-3,4-methylendioxy-benzylchlorid

2-methoxy-3,4-methylenedioxybenzyl alcohol

Downstream raw materials:

(R)-5-(4-Methoxy-benzo[1,3]dioxol-5-ylmethyl)-6-((R)-1-phenyl-ethyl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

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