(S)-4-tert-Butyl-2-[(1S,2S)-2-(dimethyl-phenyl-silanyl)-1-methyl-1,2,3,4-tetrahydro-naphthalen-1-yl]-4,5-dihydro-oxazole

Base Information

• Chemical Name: (S)-4-tert-Butyl-2-[(1S,2S)-2-(dimethyl-phenyl-silanyl)-1-methyl-1,2,3,4-tetrahydro-naphthalen-1-yl]-4,5-dihydro-oxazole
• CAS No.: 283584-97-4
• Molecular Formula: C₂₆H₃₅NOSi
• Molecular Weight: 405.656
• Mol file: 283584-97-4.mol

Synonyms:(S)-4-tert-Butyl-2-[(1S,2S)-2-(dimethyl-phenyl-silanyl)-1-methyl-1,2,3,4-tetrahydro-naphthalen-1-yl]-4,5-dihydro-oxazole

Chemical Property of (S)-4-tert-Butyl-2-[(1S,2S)-2-(dimethyl-phenyl-silanyl)-1-methyl-1,2,3,4-tetrahydro-naphthalen-1-yl]-4,5-dihydro-oxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-tert-Butyl-2-[(1S,2S)-2-(dimethyl-phenyl-silanyl)-1-methyl-1,2,3,4-tetrahydro-naphthalen-1-yl]-4,5-dihydro-oxazole

There total 3 articles about (S)-4-tert-Butyl-2-[(1S,2S)-2-(dimethyl-phenyl-silanyl)-1-methyl-1,2,3,4-tetrahydro-naphthalen-1-yl]-4,5-dihydro-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(S)-4-tert-Butyl-2-[(1S,2S)-2-(dimethyl-phenyl-silanyl)-1-methyl-1,2-dihydro-naphthalen-1-yl]-4,5-dihydro-oxazole (154547-92-9) → (S)-4-tert-Butyl-2-[(1S,2S)-2-(dimethyl-phenyl-silanyl)-1-methyl-1,2,3,4-tetrahydro-naphthalen-1-yl]-4,5-dihydro-oxazole (283584-97-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jo0001131

Reference yield:

1-<4'-(S)-tert-butyloxazolin-2'-yl>naphthalene (132912-17-5) → (S)-4-tert-Butyl-2-[(1S,2S)-2-(dimethyl-phenyl-silanyl)-1-methyl-1,2,3,4-tetrahydro-naphthalen-1-yl]-4,5-dihydro-oxazole (283584-97-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Li / tetrahydrofuran / 3.5 h

1.2: diethyl ether / 87 h / -72 °C

1.3: 90 percent / -72 - -20 °C

2.1: 82 percent / H₂ / Pd/C / ethanol

With hydrogen; lithium; palladium on activated charcoal; In tetrahydrofuran; ethanol; 1.1: Metallation / 1.2: Addition / 1.3: Methylation / 2.1: Catalytic hydrogenation;

DOI:10.1021/jo0001131

Reference yield:

phenyldimethylsilyl chloride (768-33-2) → (S)-4-tert-Butyl-2-[(1S,2S)-2-(dimethyl-phenyl-silanyl)-1-methyl-1,2,3,4-tetrahydro-naphthalen-1-yl]-4,5-dihydro-oxazole (283584-97-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Li / tetrahydrofuran / 3.5 h

1.2: diethyl ether / 87 h / -72 °C

1.3: 90 percent / -72 - -20 °C

2.1: 82 percent / H₂ / Pd/C / ethanol

With hydrogen; lithium; palladium on activated charcoal; In tetrahydrofuran; ethanol; 1.1: Metallation / 1.2: Addition / 1.3: Methylation / 2.1: Catalytic hydrogenation;

DOI:10.1021/jo0001131

upstream raw materials:

(S)-4-tert-Butyl-2-[(1S,2S)-2-(dimethyl-phenyl-silanyl)-1-methyl-1,2-dihydro-naphthalen-1-yl]-4,5-dihydro-oxazole

1-<4'-(S)-tert-butyloxazolin-2'-yl>naphthalene

phenyldimethylsilyl chloride

Downstream raw materials:

3-[(1R,2S)-2-(Dimethyl-phenyl-silanyl)-1-methyl-1,2,3,4-tetrahydro-naphthalen-1-yl]-propionic acid ethyl ester

Dimethyl-[(1R,2S)-1-methyl-1-((E)-2-nitro-vinyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-phenyl-silane

Dimethyl-[(1R,2S)-1-methyl-1-(2-nitro-ethyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-phenyl-silane

3-benzhydryl-9b-methyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole